Threshold of Toxicological Concern

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The Threshold of Toxicological Concern (TTC) is a limit value for substances of unknown toxicity , but known chemical structure . Below the limit, it is assumed that the substance is harmless at a certain exposure in this concentration; Above the limit value, further studies and a toxicity determination (usually with animal experiments ) are required. The TTC is determined in a decision tree from data on substances with a similar structure, the limit values ​​are set low ( precautionary principle ).

use

The European Food Safety Authority (EFSA) has checked the TTC concept and uses it consistently for flavorings and pesticides in groundwater.

In Switzerland, the application of the TTC concept for drinking water from 2009 onwards was described by the Federal Office of Public Health as an enforcement aid and was made mandatory by law with the revision of the Foreign and Ingredients Ordinance (FIV) in 2015. The trigger for this launch were at Hardwasser AG proven Chlorbutadiene still present limits were set for which neither sufficient toxicity data. With the help of the TTC procedure limit values ​​were defined and confirmed after a later toxicity determination ( Ames test and chromosome aberration test ).

literature

  • International Life Sciences Institutes Europe (ILSI): Threshold of toxicological concern (TTC) - a tool for assessing substances of unknown toxicity present at low levels in the diet . ( PDF; 0.4 MB )

Individual evidence

  1. ↑ EFSA Scientific Committee (Ed.): Scientific Opinion on Exploring options for providing advice about possible human health risks based on the concept of Threshold of Toxicological Concern (TTC) . In: EFSA Journal, Volume 10 Issue 7, July 2012. ( [1] )
  2. ↑ EFSA: Threshold of Toxicological Concern, FAQ No. 3. [2]
  3. ↑ Federal Office of Public Health: Assessment of contaminants in drinking water using the “Threshold of Toxicological Concern” (TTC) concept . Liebefeld, January 20, 2009. ( PDF )
  4. ↑ Federal Office of Public Health: Dealing with non-regulated foreign substances in drinking water . Bern, January 16, 2012. ( PDF )
  5. ^ Ordinance of the EDI on foreign substances and ingredients in food. (Foreign and Ingredients Ordinance , FIV) SR 817.021.23. in Appendix 4 list of the maximum concentrations (tolerance and limit values) for other foreign substances or ingredients . ( [3] )
  6. ↑ Beat J. Brüschweiler ( Federal Food Safety and Veterinary Office ): The TTC Approach in Practice and its Impact on Risk Assessment and Risk Management in Food Safety. A Regulatory Toxicologist's Perspective . In: Swiss Chemical Society: Chimia . Vol. 68, No. 10, 2014. pp. 711f ( Case 1: Polychlorinated Butadienes in Drinking Water ). ( PDF; 0.2 MB )