Thrombophilia
| Classification according to ICD-10 | |
|---|---|
| D68.5 | Primary thrombophilia |
| D68.6 | Other thrombophilia |
| ICD-10 online (WHO version 2019) | |
The thrombophilia ( give a wiki. Thrombus , lumps 'and phileein love') or thrombosis is a genetic or acquired tendency to form blood clots within blood vessels ( thrombosis ) or embolism due to altered properties of blood cells, blood plasma, blood flow and / or vessel walls .
The thrombophilia z. B. by
- increased platelet or erythrocyte aggregation (the tendency of blood platelets and red blood cells to clump together),
- increased blood viscosity,
- Increase in coagulation-promoting or decrease in anti-coagulation factors,
- Disorders of fibrinolysis ,
- rheological disorders with arterial hypercirculation or venous hypocirculation.
Local changes in the blood vessels can also lead to the formation of thrombi . Pathological changes in the vascular wall caused by arteriosclerosis or inflammation can lead to the accumulation and clumping of platelets and thus to vascular occlusion. The disturbance of the blood flow at narrow points ( stenoses ) increases this tendency to local thrombosis. The term thrombophilia, however, describes a general tendency to form clots, regardless of local factors.
Some causes of thrombophilia (hereditary and / or acquired)
- APC resistance ( factor V Leiden mutation , less often factor V Cambridge)
- Prothrombin mutation G20210A (factor II)
- Protein C deficiency
- Protein S deficiency
- Antithrombin deficiency
- Antiphospholipid antibodies
- Thrombotic thrombocytopenic purpura
- Heparin-induced thrombocytopenia type II
- Persistently elevated factor VIIIc
- Mutations in the THBD gene
