Treadmilling

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As treadmilling or Tretmühlenmechanismus a phenomenon in which it is polymerization of actin filaments in the cytoplasm of eukaryotic cells , respectively.

When the actin polymer has reached steady state , there is a net build-up of actin at the plus end of the actin filament. At the same time there is a net degradation of actin at the negative end of the actin filament. The length of the actin filament remains constant. At the same time there is a net flow of actin monomers. This phenomenon is known as treadmilling.

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  • Bruce Alberts, Dennis Bray, Julian Lewis: Molecular Biology of the Cell , 4th Edition, Taylor & Francis, 2002, pp. 909-920, ISBN 0815340729

Individual evidence

  1. ↑ Entry on treadmill mechanism. In: Römpp Online . Georg Thieme Verlag, accessed on June 4, 2020.
  2. ↑ Molecular Cell Biology: Section 37. The Cytoskeleton I: Microfilaments . Pp. 88-125, p. 88.