Trisomy 10

Classification according to ICD-10
Q92.-	Other trisomies and partial autosomal trisomies, not elsewhere classified
Q92.8	Other specified trisomies and partial trisomies of the autosomes
ICD-10 online (WHO version 2019)

A trisomy 10 is a disability caused by a tripling ( trisomy ) of genetic material of chromosome 10s based on a genome mutation .

In people with trisomy 10, chromosome 10 or a part of it is present three times (= trisome) instead of usually two times (= disome) in all or in part of the body cells.

Classification

The following types of trisomy 10 are distinguished:

• Free trisomy 10 : Type in which chromosome 10 is completely trisome in all body cells . The karyotype of free trisomy 10 is: 47, XX + 10 or 47, XY + 10.
• Translocation trisomy 10 : Type in which chromosome 10 is completely trisome in all body cells, but one of chromosomes 10 has attached to another chromosome. A chromosome shift is called a translocation in genetics .
• Mosaic trisomy 10 : Type in which chromosome 10 is not present three times (trisome) in all body cells, but at the same time a cell line with the usual disomic set of chromosomes exists. The parallel presence of several karyotypes is called a mosaic in genetics . The karyotype of the mosaic trisomy 10 is: 46, XX / 47, XX + 10 or 46, XY / 47, XY + 10.
• Partial trisomy 10 : Type in which chromosomes 10 are present twice (disome) in all body cells, as usual, but part of one of the two chromosomes 10 is doubled, which means that one of chromosomes 10 is slightly longer than the other. The hereditary information in this section is therefore available three times (trisom).
• Microduplication syndrome

Individual evidence

1. ^ Entry on Trisomie_10 in Flexikon , a Wiki of the DocCheck company
2. ^ Mosaic trisomy 10. In: Orphanet (database for rare diseases).
3. ↑ Duplication 10q, partial. In: Orphanet (Rare Disease Database).
4. ↑ Trisomy 10q, distal. In: Orphanet (Rare Disease Database).
5. ↑ Trisomy 10p. In: Orphanet (Rare Disease Database).
6. ↑ Microduplication Syndrome 10q22.3q23.3. In: Orphanet (Rare Disease Database).

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !