Tryptase
Tryptases are enzymes that break the peptide bond of proteins using a catalytic serine residue. Like trypsin, they belong to the serine proteases and are similar to it. Tryptases are released in large quantities by mast cells .
According to a study, alpha tryptase deficiency affects 45 percent of people of European descent, 26 percent of African Americans and 10 to 20 percent of Asians .
Table of tryptases
| Gene ( HGNC ) | Gene locus | Length ( AA ) | Protein ( UniProt ) | MEROPS | EC number | OMIM | Remarks |
|---|---|---|---|---|---|---|---|
| TPSAB1 | 16p13.3 | 245 | alpha-1 | S01.143 | 3.4.21.59 | 191080 | |
| TPSAB1 | 16p13.3 | 245 | beta-1 | S01.015 | 3.4.21.59 | 191081 | |
| TPSB2 | 16p13.3 | 245 | beta-2 | S01.015 | 3.4.21.59 | 191081 | |
| TPSG1 | 16p13.3 | 301 | gamma | S01.028 | 3.4.21.- | 609341 | many tissue types |
| TPSD1 | 16p13.3 | 205 | delta | S01.054 | 3.4.21.59 | 609272 | |
| PRSS22 | 16p13.3 | 285 | epsilon | S01.252 | 3.4.21.- | 609343 | Brain specific serine protease 4 ; Respiratory epithelial cells; fetal lungs |