Urobilinogen
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| structure present in physiological medium (i-urobilinogen) | ||||||||||||||||
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| Surname | Urobilinogen | |||||||||||||||
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| Molecular formula | C 33 H 44 N 4 O 6 | |||||||||||||||
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| Molar mass | 592.73 g mol −1 | |||||||||||||||
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | ||||||||||||||||
Urobilinogen is a breakdown product of bilirubin and is therefore one of the bile pigments ( bilanes ). It is made bacterially from bilirubin that is released from the gallbladder into the intestine . 20% of the urobilinogen is reabsorbed, supplied to the liver via the portal vein , further broken down and also partially excreted in the urine . Urobilinogen is an intermediate stage in the formation of urobilin .
The normal urobilinogen concentration in the urine ranges from 0.1–1.8 mg / dl (1.7–30 µmol / l), concentrations> 2.0 mg / dl (34 µmol / l) are considered pathological .
Urobilinogen does not appear in the urine if bilirubin does not enter the intestine. A Urobilinogenurie may or may not be from a bilirubinuria be accompanied. Urobilinogen is increasingly excreted in the urine when the liver is bypassed, overloaded, or functionally restricted. Urobilinogen is kidney-accessible.
Urobilinogen is increasingly detected in the urine in:
- haemolytic anemia (increased breakdown of red blood cells)
- Constipation , bowel inflammation
- Infections of the biliary tract
- acute and chronic inflammation of the liver
- toxic liver damage, liver tumors
- Congested liver (in heart failure )
proof
Urobilinogen is easily detectable with urine test strips by coupling urobilinogen to stabilized diazonium salt. The practical detection limit is 0.4 mg / dl, values below 1 mg / dl are considered normal. While this test is not overly accurate, it is perfectly adequate for a medical evaluation. It can help identify liver damage and differentiate between the various causes of jaundice (increased bilirubin).
Web links
- Wolfgang Hübl: Urobilinogen in the urine - overview
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
