Utz Fischer

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Utz Fischer (born October 12, 1964 in Berlin ) is a German scientist in the field of RNA biology. He is Professor of Biochemistry in the Faculty of Chemistry and Pharmacy at the Biozentrum of the Julius Maximilians University of Würzburg and an associated member of the Helmholtz Institute for RNA-based Infection Research (HIRI).

Life

Fischer studied biochemistry at the Free University of Berlin . He carried out his doctorate (1989–1992) and his first postdoc research (1992-1995) at the Institute for Molecular Biology and Tumor Research (IMT) of the Philipps University of Marburg in the laboratory of Prof. Reinhard Lührmann . As a DKFZ Fellow (AIDS Scholar), Fischer conducted research between 1995 and 1997 at the Howard Hughes Medical Institute of the University of Pennsylvania (Philadelphia, USA) in the group of Prof. Gideon Dreyfuss. From 1997 to 2003 he headed an independent research group at the Max Planck Institute for Biochemistry in Martinsried. Since 2003 he has held a chair at the Biozentrum in Würzburg. Since 2019 he has been an associated member of the Helmholtz Institute for RNA-based Infection Research (HIRI), and since 2018 Associate Director of the Cancer Therapy Research Center (CTRC) at the University of Würzburg.

From 2014 to 2018, Fischer was head of the RNA-based disease therapy department at Genelux, San Diego, USA and research scientist at the Department of Radiation Medicine and Applied Sciences, University of California, San Diego , USA.

Scientific work

Fischer's research deals with the biogenesis, structure and function of macromolecular machines of RNA metabolism and their role in human diseases.

Important scientific contributions were:

  • Identification of a new class of nuclear transport signals for RNA-protein complexes
  • First description of a core export signal (NES)
  • Identification and characterization of the PRMT-5 / SMN complex, a biogenesis machinery for RNA-protein complexes
  • Structural description of the smallpox virus gene expression machinery

Publications (selection)

  • An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus, Fischer and Lührmann, Science (1990) DOI: 10.1126 / science.2143847
  • The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs, Fischer et al., Cell (1995) DOI: 10.1016 / 0092-8674 (95) 90436-0
  • The SMN-SIP1 complex has an essential role in spliceosomal U snRNP biogenesis, Fischer U, Lui Q, Dreyfuss G, Cell (1997) DOI: 10.1016 / S0092-8674 (00) 80368-2
  • A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs, Meister G, Bühler D, Pillai R, Lottspeich F, Fischer U, Nature Cell Biology (2001) DOI: 10.1038 / ncb1101-945
  • Reduced RNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy, Winkler C, Eggert C, Gradl D, Meister G, Giegerich M, Wedlich D, Fischer U, Genes & Development (2005) DOI: 10.1101 / gad.342005
  • An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs, Chari et al., Cell (2008) DOI: 10.1016 / j.cell.2008.09.020
  • Intronic miR-26b controls neuronal differentiation by repressing its host transcript, ctdsp2, Dill H, Linder B, Fehr A, Fischer U, Genes & Development (2012) DOI: 10.1101 / gad.177774.111
  • Structural Basis of Assembly Chaperone- Mediated snRNP Formation, Grimm C, Chari A, Pelz J, Kuper J, Kisker C, Diederichs K, Stark H, Schindelin H, Fischer U, Molecular Cell (2013) DOI: 10.1016 / j.molcel. 2012.12.009
  • Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders, G Stoll, OPH Pietiläinen, B Linder, J Suvisaari, C Brosi, W Hennah et al., Nature Neuroscience (2013) DOI: 10.1038 / nn.3484
  • Structural basis of Poxvirus transcription: transcribing and capping Vaccinia complexes, Hillen et al., Cell (2019) DOI: 10.1016 / j.cell.2019.11.023
  • Structural basis of poxvirus transcription: Vaccinia RNA polymerase complexes, Clemens Grimm et al., Cell (2019) DOI: 10.1016 / j.cell.2019.11.024

Web links

Individual evidence

  1. ↑ a b Helmholtz Institute for RNA-based Infection Research | HIRI. Retrieved July 14, 2020 .
  2. ^ Institute of Molecular Biology and Tumor Research (IMT). Retrieved July 13, 2020 .
  3. ^ Dreyfuss Laboratory - Home. Retrieved July 13, 2020 .
  4. ↑ UNI-INTERN 23/2003 - July 9, 2003. Accessed July 13, 2020 .
  5. ↑ Home - ctrc. Retrieved July 14, 2020 .
  6. ↑ Genelux. Retrieved July 13, 2020 .
  7. ^ Department of Radiation Medicine - UC San Diego School of Medicine. Retrieved July 13, 2020 .
  8. ^ U Fischer, R Luhrmann: An essential signaling role for the m3G cap in the transport of U1 snRNP to the nucleus . In: Science . tape 249 , no. 4970 , August 17, 1990, ISSN  0036-8075 , p. 786–790 , doi : 10.1126 / science.2143847 ( sciencemag.org [accessed July 13, 2020]).
  9. ↑ Utz Fischer, Jochen Huber, Wilbert C Boelens, Lain W Mattajt, Reinhard Lührmann: The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs . In: Cell . tape 82 , no. 3 , August 1995, p. 475-483 , doi : 10.1016 / 0092-8674 (95) 90436-0 ( elsevier.com [accessed July 13, 2020]).
  10. ↑ Ashwin Chari, Monika M. Golas, Michael Klingenhäger, Nils Neuenkirchen, Bjoern Sander: An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs . In: Cell . tape 135 , no. 3 , October 2008, p. 497-509 , doi : 10.1016 / j.cell.2008.09.020 ( elsevier.com [accessed July 13, 2020]).
  11. ^ Hauke ​​S. Hillen, Julia Bartuli, Clemens Grimm, Christian Dienemann, Kristina Bedenk: Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes . In: Cell . tape 179 , no. 7 , December 2019, p. 1525–1536.e12 , doi : 10.1016 / j.cell.2019.11.023 ( elsevier.com [accessed July 13, 2020]).
  12. ↑ Clemens Grimm, Hauke ​​S. Hillen, Kristina Bedenk, Julia Bartuli, Simon Neyer: Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes . In: Cell . tape 179 , no. 7 , December 2019, p. 1537–1550.e19 , doi : 10.1016 / j.cell.2019.11.024 ( elsevier.com [accessed July 13, 2020]).
personal data
SURNAME Fischer, Utz
BRIEF DESCRIPTION German scientist in the field of RNA biology
DATE OF BIRTH October 12, 1964
PLACE OF BIRTH Berlin