Wolfram Bode

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Wolfram Bode (born March 8, 1942 in Berlin ) is a German biochemist and crystallographer.

biography

Bode was born in Berlin and studied at the Universities of Göttingen , Tübingen and Munich as a member of the German National Academic Foundation . In 1971 he obtained his doctorate from the University of Munich with a thesis on the flagellum of bacteria. In 1972 he became a scientific assistant to Robert Huber at the Max Planck Institute for Biochemistry in Martinsried , where he subsequently devoted himself to the X-ray structure analysis of proteins. In 1983 he completed his habilitation at the LMU Munich, where he was appointed adjunct professor for physical biochemistry in 1995.

Career

He used X-ray scattering in his graduate studies . After completing his dissertation, he began to work with X-ray crystallography in the laboratory of the later Nobel Prize winner Robert Huber . In 1975 he deciphered the structure of trypsin , one of the first protease structures that could be elucidated.

His subsequent work on the structure and function of proteins contributed significantly to the understanding of many important biological processes, in particular blood coagulation , fibrinolysis and photosynthesis . In particular, the elucidation of the atomic structure of thrombin and the description of its exact function in blood coagulation was an important step in medical research and development of blood coagulation therapeutics.

With the structural analysis of astacin, a digestive enzyme of the freshwater crab Astacus, he was able not only to determine the exact geometry of the catalytic center and the characteristic environment for the entire astacin family, but also for the much larger “Metzincin” superfamily.

In 1981, Bode was awarded the X-ray Prize of the University of Giessen . In 2000 he hosted the Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors .

Publications (selection)

Web links

Individual evidence

  1. ↑ Huber, R .; Bode, W .: Structural Basis of Activation and Action of Trypsin . In: European Journal of Biochemistry . 11, 1978, pp. 114-122. doi : 10.1021 / ar50123a006 .
  2. ↑ Bode, W .; Huber, R .: Natural Protein Proteinase-Inhibitors and their Interaction with Proteinases . In: European Journal of Biochemistry . 204, 1992, pp. 433-451. doi : 10.1111 / j.1432-1033.1992.tb16654.x .
  3. ↑ Bacteria trigger blood clotting with the master key - Max Planck scientists observe for the first time how bacterial proteins activate human blood clotting factors and cause thrombosis. Max Planck Institute for Biochemistry, archived from the original ; accessed on July 10, 2020 .
  4. ↑ Stubbs, MT, Oschkinat, H., Mayr, I., Huber, R., Angliker, H., Stone, St. R. and Bode, W .: The interaction of thrombin with fibrinogen . In: Eur. J. Biochem. . 206, 1992, pp. 187-195. PMID 16480903 .
  5. ↑ Bode W: Structure and interaction modes of thrombin . In: Blood Cells, Molecules & Diseases . 36, No. 2, 2007, pp. 122-130. doi : 10.1016 / j.bcmd.2005.12.027 . PMID 16480903 .
  6. ↑ Bode, W., Gomis-Rüth, FX, Huber, R., Zwilling, R. and Stöcker, W .: Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases . In: Nature . 358, 1992, pp. 164-167. doi : 10.1038 / 358164a0 .
  7. ↑ The Metzincin Superfamily of Zinc Peptidases. Springer, Boston, MA, accessed July 12, 2020 .
  8. ↑ Table of the people awarded the Röntgen Prize uni-giessen.de. Retrieved June 13, 2020.
  9. ↑ 2000 Proteolytic Enzymes and Their Inhibitors Conference GRC. Retrieved July 18, 2020 .
personal data
SURNAME Bode, Wolfram
BRIEF DESCRIPTION German biochemist and crystallographer
DATE OF BIRTH March 8, 1942
PLACE OF BIRTH Berlin