Quarreling
| Quarreling | ||
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| Structural formula | ||
| Mass / length primary structure | 3 amino acids | |
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| Drug information | ||
| Drug class | Antihypertensive drugs | |
Zankiren ( A-72517 ) is a peptide that is very difficult to break down by enzymes . It lowers blood pressure by inhibiting renin and is therefore known as a renin inhibitor . Zankiren is said to be used as a drug against arterial hypertension . The first animal experiments have already been completed.
literature
- Naomi DL Fisher, Norman Hollenberg: Renal vascular responses to renin inhibition with zankiren in men . In: Clinical Pharmacology & Therapeutics. Vol. 57, No. 3, 1995, pp. 342-348, PMID 7697952 , doi : 10.1016 / 0009-9236 (95) 90160-4 .
- Joël Ménard, Robert S. Boger, Denise M. Moyse, Tam T. Guyene, Harriet N. Glassman, Hollis D. Kleinert: Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects . In: Circulation. Vol. 91, No. 2, 1995, pp. 330-338, PMID 7805235 , doi : 10.1161 / 01.CIR.91.2.330 .
Individual evidence
- ↑ a b A-72517. In: Rolf Sauermost: Lexicon of Biology. Volume 12: A bis Sim. Spectrum Akademischer Verlag GmbH, Munich 2003, ISBN 3-8274-0354-5 .