Cytoalbuminal dissociation
The zytoalbuminäre dissociation denotes a medical examination findings of the cerebrospinal fluid (CSF). By definition, cytoalbuminal dissociation occurs when the number of cells is normal and the total protein is increased at the same time. This constellation of findings can be found, for example, in Guillain-Barré syndrome (GBS), in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and in blocked fluid syndrome ( Nun-Froin syndrome ). The cause can be a barrier disorder. In this case, an increase in total protein without other pathological changes is also referred to as an isolated barrier dysfunction (IBD).
history
In 1910, Nonne and Froin described a proteinocytological dissociation in the context of so-called blocked liquor or compression or stop syndrome below masses in the spinal canal . In 1916, Guillain , Barré and Strohl described what is now known as Guillain-Barré syndrome. They pointed to the “dissociation albumino-cytologique” which is noticeable in this disease.
Individual evidence
- ↑ J. Brettschneider et al .: Isolated blood-cerebrospinal fluid barrier dysfunction: prevalence and associated diseases . J Neurol. 2005 Sep; 252 (9): 1067-73. Epub 2005 Apr 1. PMID 15789126
- ↑ Uwe K. Zettl, R. Lehmitz (author), E. Mix: Clinical Liquordiagnostik . De Gruyter 2005, p. 10. ISBN 978-3110181692
- ↑ HW Delank, E. Machetan: The syndrome of the "proteino-cytological dissociation" in the cerebrospinal fluid . Journal of Neurology, Volume 174, Number 2, 189-198. ( doi: 10.1007 / BF00243485 )