Nizatidine: Difference between revisions
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==History and development== |
==History and development== |
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Nizatidine was developed by [[Eli Lilly and Company|Eli Lilly]], and was first marketed in [[1987]]. It is considered to be equipotent with [[ranitidine]] and differs by the substitution of a [[thiazole]]-ring in place of the [[furan]]-ring in ranitidine. In [[September 2000]] Eli Lilly announced that they will sell the sales and marketing rights for Axid, to [[Reliant Pharmaceuticals]]. <ref name="encyclopedia"> |
Nizatidine was developed by [[Eli Lilly and Company|Eli Lilly]], and was first marketed in [[1987]]. It is considered to be equipotent with [[ranitidine]] and differs by the substitution of a [[thiazole]]-ring in place of the [[furan]]-ring in ranitidine. In [[September 2000]] Eli Lilly announced that they will sell the sales and marketing rights for Axid, to [[Reliant Pharmaceuticals]]. <ref name="encyclopedia">[http://www.encyclopedia.com/doc/1G1-65062714.html?Q=%22axid%22 Eli Lilly and Company and Reliant Pharmaceuticals Announce<!-- Bot generated title -->]</ref> Subsequently, Reliant developed the oral solution of Axid and got [[FDA]] approval in May 2004 and started marketing it. <ref name="reliant2004">[http://www.reliantrx.com/investor/press_releases/072604.htm Reliant Pharmaceuticals : Press Releases<!-- Bot generated title -->]</ref> However, a year later they sold rights (including the issued patent [http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6930119.PN.&OS=PN/6930119&RS=PN/6930119 US6,930,119] protecting the product) of the Axid® Oral Solution to [http://www.braintreelabs.com/ Braintree Laboratories]. <ref name="reliant2005">[http://www.reliantrx.com/investor/press_releases/063005.htm Reliant Pharmaceuticals : Press Releases<!-- Bot generated title -->]</ref> |
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Nizatidine proved to be the last new histamine H<sub>2</sub>-receptor antagonists introduced prior to the advent of [[proton pump inhibitor]]s. |
Nizatidine proved to be the last new histamine H<sub>2</sub>-receptor antagonists introduced prior to the advent of [[proton pump inhibitor]]s. |
Revision as of 23:08, 26 March 2008
File:Nizatidine.png | |
Clinical data | |
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License data |
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Pregnancy category |
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Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | >70% |
Protein binding | 35% |
Metabolism | Hepatic |
Elimination half-life | 1-2 hours |
Excretion | Renal |
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CAS Number | |
PubChem CID | |
DrugBank | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.155.683 |
Chemical and physical data | |
Formula | C12H21N5O2S2 |
Molar mass | 331.46 g/mol g·mol−1 |
Nizatidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). It was developed by Eli Lilly and is marketed under the trade names Tazac® and Axid®.
Clinical use
Main article: H2-receptor antagonist
Certain preparations of nizatadine are now available over the counter in various countries including the United States.
History and development
Nizatidine was developed by Eli Lilly, and was first marketed in 1987. It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole-ring in place of the furan-ring in ranitidine. In September 2000 Eli Lilly announced that they will sell the sales and marketing rights for Axid, to Reliant Pharmaceuticals. [1] Subsequently, Reliant developed the oral solution of Axid and got FDA approval in May 2004 and started marketing it. [2] However, a year later they sold rights (including the issued patent US6,930,119 protecting the product) of the Axid® Oral Solution to Braintree Laboratories. [3]
Nizatidine proved to be the last new histamine H2-receptor antagonists introduced prior to the advent of proton pump inhibitors.
External links
References