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{{taxobox
{{taxobox
|name = Happy tree
|name = Happy tree
|image = Camptotheca acuminata - United States Botanic Garden - DSC09523.JPG
|image = CancerTree.jpg
|image_caption = Cancer Tree, ''[[Camptotheca acuminata]]''
|image_caption = ''[[Camptotheca acuminata]]''
|regnum = [[Plantae]]
|regnum = [[Plantae]]
|unranked_divisio = [[Angiosperms]]
|unranked_divisio = [[Angiosperms]]
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''Camptotheca lowreyana''
''Camptotheca lowreyana''
|}}
|}}
{{Commonscat}}


'''''Camptotheca''''' ('''happy tree''', '''cancer tree''', or '''tree of life''') is a genus of medium-sized [[deciduous]] [[tree]]s growing to {{convert|20|m|ft}} tall, native to southern [[China]] and Tibet. The genus is usually included in the [[tupelo]] family [[Nyssaceae]], but sometimes included (with the tupelos) in the [[dogwood]] family [[Cornaceae]].
'''''Camptotheca''''' ('''happy tree''', '''cancer tree''', or '''tree of life''') is a genus of medium-sized [[deciduous]] [[tree]]s growing to {{convert|20|m|ft}} tall, native to southern [[China]] and Tibet. The genus is usually included in the [[tupelo]] family [[Nyssaceae]], but sometimes included (with the tupelos) in the [[dogwood]] family [[Cornaceae]].
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There are two species:
There are two species:
*''Camptotheca acuminata'' Decne.
*''[[Camptotheca acuminata]]'' Decne.
*''Camptotheca lowreyana'' S.Y.Li
*''[[Camptotheca lowreyana]]'' S.Y.Li


The bark and stems of ''C. acuminata'' contain the [[alkaloid]] [[camptothecin]].<ref name=Li>{{ cite journal | title = Antifungal Activity of Camptothecin, Trifolin, and Hyperoside Isolated from ''Camptotheca acuminata'' | author = Li, S.; Zhang, Z.; Cain, A.; Wang, B.; Long, M.; Taylor, J. | journal = Journal of Agricultural and Food Chemistry | year = 2005 | volume = 53 | issue = 1 | pages = 32–37 | doi = 10.1021/jf0484780 | pmid = 15631505 }}</ref> Several chemical [[derivative (chemistry)|derivatives]] of camptothecin are under investigation for or used as drugs for cancer treatment, including [[irinotecan]], [[topotecan]], [[rubitecan]].<ref>{{Cite book| author = G. Samuelsson| title = Drugs of Natural Origin: a Textbook of Pharmacognosy | year = 2004 | publisher = Swedish pharmaceutical press | location = Stokkholm | edition = 5| isbn = 91-974318-4-2 }}</ref>
The bark and stems of ''C. acuminata'' contain the [[alkaloid]] [[camptothecin]].<ref name=Li>{{ cite journal | title = Antifungal Activity of Camptothecin, Trifolin, and Hyperoside Isolated from ''Camptotheca acuminata'' | author = Li, S.; Zhang, Z.; Cain, A.; Wang, B.; Long, M.; Taylor, J. | journal = Journal of Agricultural and Food Chemistry | year = 2005 | volume = 53 | issue = 1 | pages = 32–37 | doi = 10.1021/jf0484780 | pmid = 15631505 }}</ref> Several chemical [[derivative (chemistry)|derivatives]] of camptothecin are under investigation for or used as drugs for cancer treatment, including [[irinotecan]], [[topotecan]], [[rubitecan]].<ref>{{Cite book| author = G. Samuelsson| title = Drugs of Natural Origin: a Textbook of Pharmacognosy | year = 2004 | publisher = Swedish pharmaceutical press | location = Stokkholm | edition = 5| isbn = 91-974318-4-2 }}</ref>

Revision as of 14:49, 3 August 2013

Happy tree
Camptotheca acuminata
Scientific classification
Kingdom:
(unranked):
(unranked):
(unranked):
Order:
Family:
Genus:
Camptotheca

Species

Camptotheca acuminata
Camptotheca lowreyana

Camptotheca (happy tree, cancer tree, or tree of life) is a genus of medium-sized deciduous trees growing to 20 metres (66 ft) tall, native to southern China and Tibet. The genus is usually included in the tupelo family Nyssaceae, but sometimes included (with the tupelos) in the dogwood family Cornaceae.

The name "happy tree" is a direct translation of the Chinese name xi shu (Simplified Chinese:喜树).

There are two species:

The bark and stems of C. acuminata contain the alkaloid camptothecin.[1] Several chemical derivatives of camptothecin are under investigation for or used as drugs for cancer treatment, including irinotecan, topotecan, rubitecan.[2]

C. acuminata also contains the chemical compounds trifolin and hyperoside.[1]

References

  1. ^ a b Li, S.; Zhang, Z.; Cain, A.; Wang, B.; Long, M.; Taylor, J. (2005). "Antifungal Activity of Camptothecin, Trifolin, and Hyperoside Isolated from Camptotheca acuminata". Journal of Agricultural and Food Chemistry. 53 (1): 32–37. doi:10.1021/jf0484780. PMID 15631505.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ G. Samuelsson (2004). Drugs of Natural Origin: a Textbook of Pharmacognosy (5 ed.). Stokkholm: Swedish pharmaceutical press. ISBN 91-974318-4-2.