Streptomyces toxytricini: Difference between revisions
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{{Short description|Species of bacterium}} |
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{{Taxobox |
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| domain = [[Bacterium|Bacteria]] |
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| phylum = [[Actinobacteria]] |
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| ordo = [[Actinomycetales]] |
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| familia = [[Streptomycetaceae]] |
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| genus = ''[[Streptomyces]]'' |
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| species = '''''S. toxytricini''''' |
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| binomial = ''Streptomyces toxytricini'' |
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'''''Streptomyces toxytricini''''' is a [[Gram-positive]] [[bacteria|bacterium]] belonging to the [[genus]] ''[[Streptomyces]]''. It produces the [[pancreatic lipase]] [[enzyme inhibitor|inhibitor]] [[lipstatin]],<ref>{{cite journal | |
'''''Streptomyces toxytricini''''' is a [[Gram-positive]] [[bacteria|bacterium]] belonging to the [[genus]] ''[[Streptomyces]]''. It produces the [[pancreatic lipase]] [[enzyme inhibitor|inhibitor]] [[lipstatin]],<ref>{{cite journal |vauthors=Weibel E, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H |title=Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity |journal=J Antibiot (Tokyo) |volume=40 |issue=8 |pages=1081–5 |year=1987 |pmid=3680018 |doi=10.7164/antibiotics.40.1081|doi-access=free }}</ref> of which the antiobesity drug [[orlistat]] is a derivative.<ref name="OriginalSynth">{{cite journal |vauthors=Barbier P, Schneider F | title = Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin | journal = Helvetica Chimica Acta | volume = 70 | issue = 1 | pages = 196–202 | year = 1987 | doi = 10.1002/hlca.19870700124}}</ref> |
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== References == |
== References == |
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{{Reflist}} |
{{Reflist}} |
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== Further reading == |
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* {{cite journal|last1=Zhu|first1=Tingheng|last2=Wang|first2=Lingfei|last3=Wang|first3=Weixia|last4=Hu|first4=Zhongce|last5=Yu|first5=Meilan|last6=Wang|first6=Kun|last7=Cui|first7=Zhifeng|title=Enhanced production of lipstatin from Streptomyces toxytricini by optimizing fermentation conditions and medium|journal=Journal of General and Applied Microbiology|date=April 3, 2014|volume=60|issue=3|pages=106–111|doi=10.2323/jgam.60.106|pmid=25008166|doi-access=free}} |
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==External links== |
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*[http://bacdive.dsmz.de/index.php?search=16057&submit=Search Type strain of ''Streptomyces toxytricini'' at Bac''Dive'' - the Bacterial Diversity Metadatabase] |
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{{Taxonbar|from=Q5850486}} |
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[[Category:Streptomyces|toxytricini]] |
[[Category:Streptomyces|toxytricini]] |
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[[Category:Bacteria described in 1957]] |
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{{bacteria-stub}} |
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{{Streptomyces-stub}} |
Latest revision as of 23:24, 12 April 2024
Streptomyces toxytricini | |
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Scientific classification | |
Domain: | Bacteria |
Phylum: | Actinomycetota |
Class: | Actinomycetia |
Order: | Streptomycetales |
Family: | Streptomycetaceae |
Genus: | Streptomyces |
Species: | S. toxytricini
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Binomial name | |
Streptomyces toxytricini Preobrazhenskaya & Sveshnikova 1957
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Streptomyces toxytricini is a Gram-positive bacterium belonging to the genus Streptomyces. It produces the pancreatic lipase inhibitor lipstatin,[1] of which the antiobesity drug orlistat is a derivative.[2]
References[edit]
- ^ Weibel E, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H (1987). "Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity". J Antibiot (Tokyo). 40 (8): 1081–5. doi:10.7164/antibiotics.40.1081. PMID 3680018.
- ^ Barbier P, Schneider F (1987). "Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin". Helvetica Chimica Acta. 70 (1): 196–202. doi:10.1002/hlca.19870700124.
Further reading[edit]
- Zhu, Tingheng; Wang, Lingfei; Wang, Weixia; Hu, Zhongce; Yu, Meilan; Wang, Kun; Cui, Zhifeng (April 3, 2014). "Enhanced production of lipstatin from Streptomyces toxytricini by optimizing fermentation conditions and medium". Journal of General and Applied Microbiology. 60 (3): 106–111. doi:10.2323/jgam.60.106. PMID 25008166.
External links[edit]