Β-arrestin
| ARRB1 | ||
|---|---|---|
|
||
| according to PDB 2IV8 | ||
| other names |
Arrestin, Beta 1; Arrestin 2; ARR1; Beta-arrestin-1; Arrestin beta-1; ARB1 |
|
| Properties of human protein | ||
| Mass / length primary structure | 418 amino acids / 47.1 kilodaltons | |
| Isoforms | 2 | |
| Identifier | ||
| Gene names | ARRB1 ARB1; ARR1 | |
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 408 | 109689 |
| Ensemble | ENSG00000137486 | ENSMUSG00000018909 |
| UniProt | P49407 | Q8BWG8 |
| Refseq (mRNA) | NM_004041 | NM_177231 |
| Refseq (protein) | NP_004032 | NP_796205 |
| Gene locus | Chr 11: 75.26 - 75.35 Mb | Chr 7: 99.54 - 99.61 Mb |
| PubMed search | 408 |
109689
|
β-Arrestin (also β-Arrestin 1, Arrestin 2) is a protein that regulates the activity of G-protein-coupled receptors (GPCR). It leads to a reduced activation of the GPCR, to an endocytosis of the GPCR and connects the GPCR signal path with the Src signal path , ERK signal path and the Akt signal path.
Individual evidence
- ^ S. Dalle, MA Ravier, G. Bertrand: Emerging roles for β-arrestin-1 in the control of the pancreatic β-cell function and mass: new therapeutic strategies and consequences for drug screening. In: Cell Signal. Volume 23, Issue 3, 2011, pp. 522-528. doi: 10.1016 / j.cellsig.2010.09.014 . PMID 20849951 .