β-bungarotoxin
| Beta-bungarotoxin B chain-like | ||
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| according to PDB 1bun | ||
| Mass / length primary structure | 28 amino acids , 2,925 Da | |
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β-Bungarotoxin is a protein and neurotoxin from the snake Bungarus multicinctus .
properties
β-Bungarotoxin is produced in the poison gland. It is a heterodimer with phospholipase A 2 activity. It occurs in two isoforms , β 1 -ungarotoxin and β 2 -ungarotoxin. κ-bungarotoxin and α-bungarotoxin have a postsynaptic effect , while β-bungarotoxin has a presynaptic effect.
Web links
Individual evidence
- ↑ YC Cheng, JJ Wang, LS Chang: B chain is a functional subunit of beta-bungarotoxin for inducing apoptotic death of human neuroblastoma SK-N-SH cells. In: Toxicon: official journal of the International Society on Toxinology. Volume 51, Number 2, February 2008, pp. 304-315, doi : 10.1016 / j.toxicon.2007.10.006 , PMID 18037462 .
- ↑ UK Ranawaka, DG Lalloo, HJ de Silva: Neurotoxicity in snakebite-the limits of our knowledge. In: PLoS neglected tropical diseases. Volume 7, number 10, 2013, p. E2302, doi : 10.1371 / journal.pntd.0002302 , PMID 24130909 , PMC 3794919 (free full text).