κ-bungarotoxin
| Kappa bungarotoxin | ||
|---|---|---|
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| according to PDB 1KBA | ||
| other names |
Kappa-1-bungarotoxin, Long neurotoxin 2, Neuronal bungarotoxin |
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| Mass / length primary structure | 87 amino acids , 9,566 Da | |
| Identifier | ||
| External IDs | ||
κ-bungarotoxin (synonym toxin F ) is a protein and neurotoxin from the snake Bungarus multicinctus .
properties
κ-bungarotoxin is produced in the poison gland. It binds and inhibits nicotinic acetylcholine receptors with an IC 50 of 100 nM. It is a reversible antagonist in particular of alpha-3 / CHRNA3 and, to a lesser extent, of alpha-4 / CHRNA4 acetylcholine receptors. In contrast to the related α-bungarotoxin , κ -bungarotoxin inhibits the ganglion ciliare of chickens, which is why it was named in the series with the other bungarotoxins with the Greek letter 'κ' (an allusion to the Latin ciliare ). Like α-bungarotoxin, κ-bungarotoxin acts postsynaptically , while β-bungarotoxin acts presynaptically.
Web links
Individual evidence
- ↑ RH Loring, D. Andrews, W. Lane, RE Zigmond: Amino acid sequence of toxin F, a snake venom toxin that blocks neuronal nicotinic receptors. In: Brain research. Volume 385, Number 1, October 1986, pp. 30-37, PMID 3021284 .
- ↑ VA Chiappinelli: Kappa bungarotoxin: a test for the neuronal nicotinic receptor in the avian ciliary ganglion. In: Brain research. Volume 277, Number 1, October 1983, pp. 9-22, PMID 6139146 .
- ↑ UK Ranawaka, DG Lalloo, HJ de Silva: Neurotoxicity in snakebite-the limits of our knowledge. In: PLoS neglected tropical diseases. Volume 7, number 10, 2013, p. E2302, doi : 10.1371 / journal.pntd.0002302 , PMID 24130909 , PMC 3794919 (free full text).