α-bungarotoxin

Alpha-bungarotoxin isoform V31
	according to PDB 1IDI
other names	Long neurotoxin 1
	Existing structure data : PDB 1HC9 , PDB 2QC1 , PDB 4HQP
Mass / length primary structure	95 amino acids , 10,313 Da
Identifier
External IDs	UniProt : P60616 ;
	Orthologue

α-Bungarotoxin Isoform V31 is a protein and neurotoxin from the snake Bungarus multicinctus .

properties

α-Bungarotoxin is produced in the poison gland. It binds and inhibits nicotinic acetylcholine receptors . It is an antagonist in particular of muscular alpha-1 / CHRNA1 and neuronal alpha-7 / CHRNA7. By binding up to two molecules of α-bungarotoxin, the binding of acetylcholine is inhibited. However, binding of one molecule is sufficient to inhibit the nicotinic acetylcholine receptor. In contrast to the related κ-bungarotoxin , α-bungarotoxin does not inhibit the ciliary ganglion of chickens. Like κ-bungarotoxin, α-bungarotoxin has a postsynaptic effect , while β-bungarotoxin has a presynaptic effect. Due to its structure, α-bungarotoxin is counted among the three-finger toxins. It has five disulfide bridges .

Web links

MeSH Α-bungarotoxin

Individual evidence

↑ HS Young, LG Herbette, V. Skita: Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction. In: Biophysical Journal. Volume 85, Number 2, August 2003, pp. 943-953, doi : 10.1016 / S0006-3495 (03) 74533-0 , PMID 12885641 , PMC 1303215 (free full text).
↑ Jean-Pierre Changeux , M. Kasai, CY Lee: Use of a snake venom toxin to characterize the cholinergic receptor protein. In: Proceedings of the National Academy of Sciences . Volume 67, Number 3, November 1970, pp. 1241-1247, PMID 5274453 , PMC 283343 (free full text).
↑ VA Chiappinelli: Kappa bungarotoxin: a test for the neuronal nicotinic receptor in the avian ciliary ganglion. In: Brain research. Volume 277, Number 1, October 1983, pp. 9-22, PMID 6139146 .
↑ UK Ranawaka, DG Lalloo, HJ de Silva: Neurotoxicity in snakebite-the limits of our knowledge. In: PLoS neglected tropical diseases. Volume 7, number 10, 2013, p. E2302, doi : 10.1371 / journal.pntd.0002302 , PMID 24130909 , PMC 3794919 (free full text).
↑ L. Moise, A. Piserchio, VJ Basus, E. Hawrot: NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor. In: Journal of Biological Chemistry . Volume 277, Number 14, April 2002, pp. 12406-12417, doi : 10.1074 / jbc.M110320200 , PMID 11790782 .

[1] HS Young, LG Herbette, V. Skita: Alpha-bungarotoxin binding to acetylcholine receptor membranes studied by low angle X-ray diffraction. In: Biophysical Journal. Volume 85, Number 2, August 2003, pp. 943-953, doi : 10.1016 / S0006-3495 (03) 74533-0 , PMID 12885641 , PMC 1303215 (free full text).

[2] Jean-Pierre Changeux , M. Kasai, CY Lee: Use of a snake venom toxin to characterize the cholinergic receptor protein. In: Proceedings of the National Academy of Sciences . Volume 67, Number 3, November 1970, pp. 1241-1247, PMID 5274453 , PMC 283343 (free full text).

[3] VA Chiappinelli: Kappa bungarotoxin: a test for the neuronal nicotinic receptor in the avian ciliary ganglion. In: Brain research. Volume 277, Number 1, October 1983, pp. 9-22, PMID 6139146 .

[4] UK Ranawaka, DG Lalloo, HJ de Silva: Neurotoxicity in snakebite-the limits of our knowledge. In: PLoS neglected tropical diseases. Volume 7, number 10, 2013, p. E2302, doi : 10.1371 / journal.pntd.0002302 , PMID 24130909 , PMC 3794919 (free full text).

[5] L. Moise, A. Piserchio, VJ Basus, E. Hawrot: NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor. In: Journal of Biological Chemistry . Volume 277, Number 14, April 2002, pp. 12406-12417, doi : 10.1074 / jbc.M110320200 , PMID 11790782 .