1000 genomes project

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The 1000 Genome Project is an international project in which - as announced in January 2008 - it was planned to sequence the genomes of around 2500 people by the end of 2011 in order to create a detailed catalog of human genetic variations, including single nucleotide Polymorphisms , INDELs and structural variations such as copy number variations . This would be by far the most extensive record of human genomes to date. To realize this project, institutes from many countries worked together, including the USA , England , the People's Republic of China and Germany . The complete database is made available to scientists worldwide free of charge and enriches all areas of the natural sciences .

In June 2008, three companies involved in the development of new sequencing technologies joined the project.

In December 2008, the first preliminary data from four individuals were published as part of a pilot project. In October 2010, the publication of sequence data of entire genomes from 185 individuals followed as part of the completion of the pilot project of the 1000 Genome Project. Furthermore, in February 2011 the publication of a bioinformatic analysis of genomic structural variants (SVs) - including copy number variants (English CNVs) - by the SV analysis group of the 1000 Genome Project appeared.

In October 2012 it became known that the goal had been achieved and that the genetic data of more than 1,000 people had been read and published.

Web links

Individual evidence

  1. a b http://www.1000genomes.org/
  2. ^ G. Spencer: International Consortium Announces the 1000 Genomes Project. National Human Genome Research Institute (NHGRI), January 22, 2008. (Website)
  3. ^ Geoff Spencer: Three Sequencing Companies Join 1000 Genomes Project. (PDF; 79 kB) In: www.1000genomes.org. National Human Genome Research Institute (NHGRI), June 11, 2008, accessed July 1, 2013 .
  4. ^ 1000 Genomes Project Consortium (2010). A map of human genome variation from population-scale sequencing . In: Nature . Vol. 467, pp. 1061-1073. PMID 20981092
  5. Mills, RE et al. (2011). Mapping copy number variation by population-scale genome sequencing. In: Nature . Vol. 470, pp. 59-65. PMID 21293372
  6. genetic material published. 1,000 genome project has achieved its goal: kma online ( Memento from February 28, 2013 in the Internet Archive )