Indel
The word indel (plural: indels ) is a amalgamation of in sertion and Del Etion with mutations in the genome.
The designation Indel is used to summarize insertions and deletions where, due to their often similar effects, they are either indistinguishable or have the same result. In particular, resulting polymorphisms which are based on a combined deletion / insertion mutation are referred to as indels; for example in the genetic examination of dog and wolf populations or plant chloroplasts . According to a current definition of the 1000 Genome Project , smaller insertions and deletions with a length of no more than 50 nucleotide building blocks are called indels, while larger insertions and deletions are called structural variants (also known as copy number variants , CNVs). Indels in conserved protein-coding DNA sequences ( Conserved signature indel ) can be used to create a phylogenetic tree .
Individual evidence
- ↑ U. Väli et al .: Insertion-deletion polymorphisms (indels) as genetic markers in natural populations . BMC Genetic (2008) 9: p. 8 PMID 18211670
- ↑ P. Erixon and B. Oxelman: Whole-Gene Positive Selection, Elevated Synonymous Substitution Rates, Duplication, and Indel Evolution of the Chloroplast clpP1 Gene . PLoS ONE. (2008) 3 (1): S. e1386 PMID 18167545
- ^ 1000 Genomes Project Consortium (2010). A map of human genome variation from population-scale sequencing . In: Nature . Vol. 467, pp. 1061-1073. PMID 20981092