7SL RNA

Structure of the SRP-RNA in humans.

In mammals, 7SL-RNA , also 7S-RNA , is a mostly double-stranded ribonucleic acid (RNA) which is transcribed by RNA polymerase III and which is not translated . The RNA is about 300 nucleotides long and has a sedimentation coefficient of 7S. It is the backbone of the signal recognition particle (SRP, signal recognition particle ), which is composed of RNA and six proteins. SRP is important for the cotranslational transport of proteins and directs the ribosome to the membrane of the endoplasmic reticulum .

The Alu family , a gene family of SINEs , is believed to have arisen from a duplicate of a 7SL RNA gene.

In baker's yeast the RNA is slightly longer (11S), in Escherichia coli the sedimentation coefficient of the RNA is 4.5S and has a length of 114 nucleotides.

Individual evidence

1. ^ Pool, MR. (2005): Signal recognition particles in chloroplasts, bacteria, yeast and mammals . In: Mol Membr Biol . 22 (1-2); 3-15; PMID 16092520 ; doi : 10.1080 / 09687860400026348