Angiotensins
Angiotensin I and Angiotensin II ( dome models )
Angiotensins , formerly Angiotonine or Hypertensine are one to tissue hormones counting group of peptide hormones , which by enzymatic cleavage by various peptidases from angiotensinogen the liver are formed and through a narrowing or contracting effect on the blood vessels to the blood pressure maintained can or increase and affect the adrenal glands (increased release of aldosterone ). Angiotensins include:
| Name of the angiotensin | Amino acid sequence | Activating peptidase |
|---|---|---|
| Angiotensin I (Angiotensin 1-10) | D R V Y I H P F H L | Renin |
| Angiotensin 1-9 | DRVYIHPFH | ACE2 |
| Angiotensin II (angiotensin 1-8) | DRVYIHPF | ACE |
| Angiotensin 1-7 | DRVYIHP | Neprilysin |
| Angiotensin III (angiotensin 2-8) | RVYIHPF | unknown |
| Angiotensin IV (angiotensin 3-8) | VYIHPF | unknown |
The drugs that are used to lower high blood pressure include, above all, the ACE inhibitors and the AT1 antagonists .