Anne Grapin-Botton

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Anne Grapin-Botton (born July 1, 1967 in La Rochelle ) is a French biologist and director at the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden .

Life

Grapin-Botton studied biology at UPMC University Pierre and Marie Curie (Paris VI) and graduated in 1991 in molecular and cell pharmacology. In 1995 she did her doctorate there with a research focus on brain development . She then worked as a postdoctoral fellow at Harvard University . In 2001 she became research group leader in the group for pancreatic development and cancer at the ISREC (Swiss Institute for Experimental Cancer Research) and then at the Ecole Polytechnique Fédérale de Lausanne in Switzerland. In 2012 she moved to the Danish Stem Cell Center at the University of Copenhagen as professor of developmental biology . Since August 2018 she has been director at the Max Planck Institute for Molecular Cell Biology and Genetics. Grapin-Botton has received multiple awards and grants, including a Human Frontiers Science Program (HFSP) Long Term Fellowship.

Act

Grapin-Botton is a renowned expert in developmental and stem cell biology. They pioneered human in the cultivation and lessons from embryonic stem progenitor cells of the pancreas in organoids called miniature organs that are grown in the laboratory. The main focus of her work is pancreas research. In Dresden, Grapin-Botton and her group will research the way in which individual cells in a group work together to form an organ. Specifically, Grapin-Botton and her research group investigate the influence of cell and organ architecture on the decisions of precursor cells to form special cell types, such as a cell of the pancreas or an intestinal cell. The researchers are also looking into the question of how individual cells act in a community to form an organ.

Fonts

  • Larsen, Hjalte L., Laura Martín-Coll, Alexander V. Nielsen, Chris VE Wright, Ala Trusina, Yung Hae Kim & Anne Grapin-Botton (2017) Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis. Nat Commun. , 8 (1): 605. doi: 10.1038 / s41467-017-00258-4 .
  • Petersen, Maja BK, Ajuna Azad, Camilla Ingvorsen, Katia Hess, Matthias Hansson, Anne Grapin-Botton & Christian Honoré (2017) Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation . Stem Cell Reports . 9 (4): 1246-1261. doi: 10.1016 / j.stemcr.2017.08.009 .
  • Kim, Yung Hae, Hjalte List Larsen, Paul Rue, Laurence A. Lemaire, Jorge Ferrer & Anne Grapin-Botton (2015). Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas. PLoS Biology , 13 (3), e1002111, doi: 10.1371 / journal.pbio.1002111 .
  • Greggio, Chiara, Filippo De Franceschi, Manuel Figueiredo-Larsen, Samy Gobaa, Adrian Ranga, Henrik Semb, Matthias Lutolf & Anne Grapin-Botton (2013). Artificial three-dimensional niches deconstruct pancreas development in vitro. Development , 140 (21), 4452-4462, doi: 10.1242 / dev.096628 .
  • Cortijo, Cedric, Mathieu Gouzi, Fadel Tissir & Anne Grapin-Botton (2012). Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis. Cell Reports , 2 (6), 1593-1606, doi: 10.1016 / j.celrep.2012.10.016 .
  • Johansson, Kerstin A., Umut Dursun, Nathalie Jordan, Guoqiang Gu, Friedrich Beermann, Gérard Gradwohl & Anne Grapin-Botton (2007). Temporal Control of Neurogenin3 Activity in Pancreas Progenitors Reveals Competence Windows for the Generation of Different Endocrine Cell Types. Developmental Cell , 12 (3), 457-465, doi: 10.1016 / j.devcel.2007.02.010 .

Individual evidence

  1. ↑ Grapin-Botton, Anne. Retrieved May 28, 2020 .
  2. ↑ MPI-CBG: Pancreas Research - Prof. Anne Grapin-Botton new director at the MPI-CBG • diabetologie-online. Retrieved May 28, 2020 .
personal data
SURNAME Grapin botton, Anne
BRIEF DESCRIPTION French biologist
DATE OF BIRTH July 1, 1967
PLACE OF BIRTH La Rochelle