Bernd Pichler

Bernd Pichler (born December 26, 1969 ) is a German biomedical engineer and expert in preclinical and molecular imaging as well as biomedical technology for imaging processes . He holds the Chair for Preclinical Imaging and Radiopharmacy and Director of the Werner Siemens Imaging Center at the Eberhard Karls University of Tübingen . He is the Dean of the Medical Faculty of the University of Tübingen and a member of the Board of Directors of the University Hospital of Tübingen .

Life

Pichler grew up in Pfaffenhofen an der Ilm in Bavaria. After graduating from high school, he studied electrical engineering and biomedical engineering at the Technical University of Munich . After graduating, he worked as a doctoral student at the Clinic for Nuclear Medicine at the Technical University of Munich and at the Max Planck Institute for Physics (Werner Heisenberg Institute). After receiving his doctorate ( Dr. rer. Nat. ) In 2001, he initially worked as a postdoctoral fellow at the Clinic for Nuclear Medicine. In March 2003, he moved to the University of California, Davis , as Assistant Research Professor , and worked in the Biomedical Engineering Department.

In January 2005, Pichler became head of the laboratory for preclinical imaging and imaging technology at the Eberhard Karls University of Tübingen , where he successfully completed his habilitation in 2007. Since 2008 he has been a professor at the University of Tübingen and since January 2011 he has also held the chair for preclinical imaging and radiopharmacy at the Department of Radiology, which is part of the University Hospital of Tübingen . His professorship is financed by the Werner Siemens Foundation , which is based in Switzerland.

In May 2020, Pichler was elected Dean of the Medical Faculty of the Eberhard Karls University of Tübingen .

research

Pichler researches primarily on the development of new imaging methods for preclinical basic research and clinical application. He was significantly involved in the development of an imaging process that combines positron emission tomography (PET) and magnetic resonance tomography (MRT) in one device (PET / MR). The laboratory headed by Pichler focuses primarily on basic research on new diagnostic and treatment methods in the fields of oncology , neurology , cardiology and immunology . Pichler is the owner and applicant of numerous patents on integrated PET / MR scanners and radioactive tracers .

Awards

• European Research Council Advanced Grant , 2012

• Member of the Advisory Board of the Werner Siemens Foundation , 2012

• President of the European Society for Molecular Imaging (ESMI), 2014/2015

• Member of the German Academy of Science and Engineering (acatech), 2015

• Member of the German National Academy of Natural Scientists Leopoldina , 2017

• Speaker of the Cluster of Excellence 'Image-Guided and Functionally Instructed Tumor Therapies (iFIT)' at the Eberhard-Karls-Universität Tübingen , approved by the German Research Foundation , 2019

Selected publications

• Fabian Kiessling, Bernd J Pichler, Peter Hauff: Small Animal Imaging - Basics and Practical Guide , 2nd edition, Springer International Publishing, 2017, ISBN 978-3-319-42202-2 .
• Katrin Fischer, Anna Fenzl, Dianxin Liu, Kenneth A Dyar, Maximilian Kleinert, Markus Brielmeier, Christoffer Clemmensen, Anna Fedl, Brian Finan, Andre Gessner, Martin Jastroch, Jianfeng Huang, Susanne Keipert, Martin Klingenspor, Jens C Brüning, Manfred Kneilling, Florian C Maier, Ahmed E Othman, Bernd J Pichler, Ines Pramme-Steinwachs, Stephan Sachs, Angelika Scheideler, Wolfgang M Thaiss, Henriette Uhlenhaut, Siegfried Ussar, Stephen C Woods, Julia Zorn, Kerstin Stemmer, Sheila Collins, Maria Diaz-Meco , et al .: The Scaffold Protein p62 Regulates Adaptive Thermogenesis Through ATF2 Nuclear Target Activation . In: Nature Communications . 11, No. 1, 2020, p. 2306. doi : 10.1038 / s41467-020-16230-8 . PMID 32385399 .
• Ellen Brenner, Barbara F Schörg, Fatima Ahmetlić, Thomas Wieder, Franz Joachim Hilke, Nadine Simon, Christopher Schroeder, German Demidov, Tanja Riedel, Birgit Fehrenbacher, Martin Schaller, Andrea Forschner, Thomas Eigenler, Heike Niessner, Tobias Sinnberg, Katharina S Böhm , Nadine Hömberg, Heidi Braumüller, Daniel Dauch, Stefan Zwirner, Lars Zender, Dominik Sonanini, Albert Geishauser, Jürgen Bauer, Martin Eichner, Katja J Jarick, Andreas Beilhack, Saskia Biskup, Dennis Döcker, Dirk Schadendorf, et al .: Cancer Immune Control Needs Senescence Induction by Interferon-Dependent Cell Cycle Regulator Pathways in Tumors . In: Nature Communications . 11, No. 1, 2020, p. 1335. doi : 10.1038 / s41467-020-14987-6 . PMID 32165639 .
• Martin Thunemann, Barbara F Schörg, Susanne Feil, Yun Lin, Jakob Voelkl, Matthias Golla, Angelos Vachaviolos, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Marcus Olbrich, Walter Ehrlichmann, Gerald Reischl, Christoph M Griessinger, Harald F Langer, Meinrad Gawaz, Florian Lang, Michael Schäfers, Manfred Kneilling, Bernd J Pichler, Robert Feil: Cre / lox-assisted Non-Invasive in Vivo Tracking of Specific Cell Populations by Positron Emission Tomography . In: Nature Communications . 8, No. 1, 2017, p. 444. doi : 10.1038 / s41467-017-00482-y . PMID 28874662 .
• Jennifer Schmitz, Julian Schwab, Johannes Schwenck, Qian Chen, Leticia Quintanilla-Martinez, Markus Hahn, Beate Wietek, Nina Schwenzer, Annette Staebler, Ursula Kohlhofer, Olulanu H Aina, Neil E Hubbard, Gerald Reischl, Alexander D Borowsky, Sara Brucker, Konstantin Nikolaou, Christian La Fougère, Robert D Cardiff, Bernd J Pichler, Andreas M Schmid: Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study . In: Cancer Research . 76, No. 18, 2016, pp. 5512-22. doi : 10.1158 / 0008-5472.CAN-15-0642 . PMID 27466286 . PMC 5414858 (free full text).
• Anna-Maria Rolle, Mike Hasenberg, Christopher R Thornton, Djamschid Solouk-Saran, Linda Männ, Juliane Weski, Andreas Maurer, Eliane Fischer, Philipp R Spycher, Roger Schibli, Frederic Boschetti, Sabine Stegemann-Koniszewski, Dunja Bruder, Gregory W Severin , Stella E Autenrieth, Sven Krappmann, Genna Davies, Bernd J Pichler, Matthias Gunzer, Stefan Wiehr: ImmunoPET / MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo . In: Proceedings of the National Academy of Sciences . 113, No. 8, 2016, pp. E1026–33. doi : 10.1073 / pnas.1518836113 . PMID 26787852 . PMC 4776455 (free full text).
• Christoph M Griessinger, Andreas Maurer, Christian Kesenheimer, Rainer Kehlbach, Gerald Reischl, Walter Ehrlichmann, Daniel Bukala, Maren Harant, Funda Cay, Jürgen Brück, Renate Nordin, Ursula Kohlhofer, Hans-Georg Rsameee, Leticia Quintanilla-Martinez, Martin Schaller, Martin Röcken, Bernd J Pichler, Manfred Kneilling: ⁶⁴ Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET . In: Proceedings of the National Academy of Sciences . 112, No. 4, 2015, pp. 1161–6. doi : 10.1073 / pnas.1418391112 . PMID 25587131 . PMC 4313850 (free full text).
• Florian C Maier, Hans F Wehrl, Andreas M Schmid, Julia G Mannheim, Stefan Wiehr, Chommanad Lerdkrai, Carsten Calaminus, Anke Stahlschmidt, Lan Ye, Michael Burnet, Detlef Stiller, Osama Sabri, Gerald Reischl, Mathias Staufenbiel, Olga Garaschuk, Mathias Jucker, Bernd J Pichler: Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion . In: Nature Medicine . 20, No. 12, 2014, pp. 1485-92. doi : 10.1038 / nm.3734 . PMID 25384087 .
• Hans F Wehrl, Mosaddek Hossain, Konrad Lankes, Chih-Chieh Liu, Ilja Bezrukov, Petros Martirosian, Fritz Schick, Gerald Reischl, Bernd J Pichler: Simultaneous PET-MRI reveals brain function in activated and resting state on metabolic, hemodynamic and multiple temporal scales . In: Nature Medicine . 19, No. 9, 2013, pp. 1184-9. doi : 10.1038 / nm.3290 . PMID 23975025 .
• Nele Müller-Hermelink, Heidi Braumüller, Bernd Pichler, Thomas Wieder, Reinhard Mailhammer, Katrin Schaak, Kamran Ghoreschi, Amir Yazdi, Roland Haubner, Christian A Sander, Ralph Mocikat, Markus Schwaiger, Irmgard Förster, Ralph Huss, Wolfgang A Weber, Manfred Kneilling, Martin Röcken: TNFR1 Signaling and IFN-γ Signaling Determine whether T Cells Induce Tumor Dormancy or Promote Multistage Carcinogenesis . In: Cancer Cell . 13, No. 6, 2008, pp. 507-18. doi : 10.1016 / j.ccr.2008.04.001 . PMID 18538734 .
• Martin S Judenhofer, Hans F Wehrl, Danny F Newport, Ciprian Catana, Stefan B Siegel, Markus Becker, Axel Thielscher, Manfred Kneilling, Matthias P Lichy, Martin Eichner, Karin Klingel, Gerald Reischl, Stefan Widmaier, Martin Röcken, Robert E Nutt , Hans-Jürgen Machulla, Kamil Uludag, Simon R Cherry, Claus D Claussen, Bernd J Pichler: Simultaneous PET-MRI: A new approach for functional and morphological imaging . In: Nature Medicine . 14, No. 4, 2008, pp. 459-65. doi : 10.1038 / nm1700 . PMID 18376410 .

Web links

• Werner Siemens Imaging Center - Imaging Science Center. In: Isct.uni-tuebingen.de. Retrieved June 10, 2020 . 
• The Medical Faculty of the University of Tübingen. In: uni-tuebingen.de. Retrieved June 10, 2020 . 
• The University Hospital Tübingen. In: Medizin.uni-tuebingen.de. Retrieved June 10, 2020 . 

Individual evidence

1. ^ Department of Preclinical Imaging and Radiopharmacy. In: Medizin.uni-tuebingen.de. Retrieved June 10, 2020 . 
2. ^ Staff Member - Imaging Science Center. In: Isct.uni-tuebingen.de. Retrieved June 10, 2020 . 
3. ↑ Hospital board. In: Medizin.uni-tuebingen.de. Retrieved June 10, 2020 . 
4. ^ Werner Siemens Imaging Center. In: wernersiemens-stiftung.ch. Retrieved June 10, 2020 . 
5. ^ Professor Bernd Pichler new dean of the medical faculty. In: Medizin.uni-tuebingen.de. Retrieved June 10, 2020 . 
6. ↑ ERC Advance Grant 2012. (PDF) In: Erc.europa.eu. Retrieved June 10, 2020 . 
7. ↑ Multiparametric tumor imaging and beyond: Towards understanding in vivo signals. In: cordis.europa.eu. Retrieved June 10, 2020 . 
8. ^ Foundation - committees. In: wernersiemens-stiftung.ch. Retrieved June 10, 2020 . 
9. ^ Past Presidents 2005-2019. In: e-smi.eu. Retrieved June 10, 2020 . 
10. ↑ Bernd Pichler - acatech member. In: acatech.de. Retrieved June 10, 2020 . 
11. ↑ Membership directory - Expert search - Bernd Pichler. In: leopoldina.org. Retrieved June 10, 2020 . 
12. ↑ Detail page - EXC 2180: Individualization of tumor therapies through molecular imaging and functional identification of therapeutic target structures (iFIT). In: gepris.dfg.de. Retrieved June 10, 2020 .