Birtoxin

Birtoxin
Mass / length primary structure	58 amino acids , 6,548 Da
Identifier
External IDs	UniProt : P58752 ;
Occurrence
Parent taxon	Parabuthus transvaalicus

Birtoxin is a neurotoxin from the South African thick-tailed scorpion Parabuthus transvaalicus .

properties

Birtoxin is a peptide and the most common toxin in the venom of the South African thick-tailed scorpion. In addition, the toxins Dortoxin , Bestoxin and Altitoxin are also present in the poison . Birtoxin has three disulfide bridges . Birtoxin lowers the threshold for activation of voltage-gated sodium channels in mammals . As a result, symptoms of poisoning in mammals are convulsions, the urge to urinate, tremors and an accelerated breathing rate. It shares the same N -terminal 18 amino acids with bestoxin .

Individual evidence

↑ B. Inceoglu, J. Lango, J. Wu, P. Hawkins, J. Southern, BD Hammock: Isolation and characterization of a novel type of neurotoxic peptide from the venom of the South African scorpion Parabuthus transvaalicus (Buthidae). In: European Journal of Biochemistry . Volume 268, Number 20, October 2001, pp. 5407-5413, PMID 11606203 .
Jump up ↑ B. Inceoglu, J. Lango, I. Pessah, B. Hammock: Three structurally related, highly potent, peptides from the venom of possess divergent biological activity . In: Toxicon . 45, No. 6, 2005, ISSN 0041-0101 , pp. 727-733. doi : 10.1016 / j.toxicon.2005.01.020 . PMID 15804521 .
↑ MF Martin-Eauclaire, B. Ceard, F. Bosmans, JP Rosso, J. Tytgat, PE Bougis: New "Birtoxin analogs" from Androctonus australis venom. In: Biochemical and biophysical research communications. Volume 333, Number 2, July 2005, pp. 524-530, doi : 10.1016 / j.bbrc.2005.05.148 , PMID 15963953 .

[1] B. Inceoglu, J. Lango, J. Wu, P. Hawkins, J. Southern, BD Hammock: Isolation and characterization of a novel type of neurotoxic peptide from the venom of the South African scorpion Parabuthus transvaalicus (Buthidae). In: European Journal of Biochemistry . Volume 268, Number 20, October 2001, pp. 5407-5413, PMID 11606203 .

[pmid15804521-2] Jump up ↑ B. Inceoglu, J. Lango, I. Pessah, B. Hammock: Three structurally related, highly potent, peptides from the venom of possess divergent biological activity . In: Toxicon . 45, No. 6, 2005, ISSN 0041-0101 , pp. 727-733. doi : 10.1016 / j.toxicon.2005.01.020 . PMID 15804521 .

[3] MF Martin-Eauclaire, B. Ceard, F. Bosmans, JP Rosso, J. Tytgat, PE Bougis: New "Birtoxin analogs" from Androctonus australis venom. In: Biochemical and biophysical research communications. Volume 333, Number 2, July 2005, pp. 524-530, doi : 10.1016 / j.bbrc.2005.05.148 , PMID 15963953 .