Blood-liquor barrier

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The blood-liquor barrier is a physiological barrier between the bloodstream and the liquor system of the central nervous system . Together with the blood-brain barrier to be distinguished from it , it separates the nerve tissue from the blood.

structure

The blood-liquor barrier is represented by the capillary endothelium of the blood vessels, the basement membrane , and the epithelium of the choroid plexus . It is completely permeable only to water and dissolved gases such as oxygen and carbon dioxide , hardly permeable to electrolytes and completely impermeable to most other molecules. These can only cross the blood-liquor barrier if they are actively absorbed and secreted by the plexus epithelia .

function

Together with the blood-brain barrier and other structures, the blood-liquor barrier protects the brain from substances in the blood. These barriers also ensure that the brain is adequately supplied with oxygen, glucose as an energy carrier, other nutrients and amino acids. Specific concentrations of ions, hormones and transmitters must be adhered to, since the homeostasis of the brain is only allowed to move within very narrow limits.

history

After the discovery of the blood-brain barrier by Paul Ehrlich in 1885, Friedrich Karl Walter and Hugo Spatz independently of one another came to the conclusion in 1933 that it had to be distinguished from the blood-liquor barrier. Walter also took the view that the blood supplies the brain with nutrients, while other scientists still saw the nutrient supplier in the liquor. After decades of controversial discussions, the existence of the blood-brain barrier was proven for the first time in 1967. The blood-liquor barrier and its location in the epithelium of the choroid plexus could finally be proven in 1969.

literature

  • Peter Brenner: The structure of the blood-brain and blood-liquor barriers. A literature study. Dissertation, Ludwig Maximilians University Munich, 2006.
  • Uwe K. Zettl, Reinhard Lehmitz, Eilhard Mix: Clinical liquor diagnostics. Walter de Gruyter, 2005. ISBN 9783110181692 . P. 58ff.

Individual evidence

  1. ↑ a b Peter Brenner: The structure of the blood-brain and blood-liquor barrier. A literature study. Dissertation, Ludwig Maximilians University Munich, 2006. pp. 2–9
  2. ↑ Friedrich Karl Walter: The general basics of the exchange of substances between the central nervous system and the rest of the body. In: Archive for Psychiatry and Nervous Diseases 101, 1930. pp. 195–230
  3. ↑ Hugo Spatz: The importance of the vital color for the theory of the exchange of substances between the central nervous system and the rest of the body. In: Archive for Psychiatry and Nervous Diseases 101, 1933. pp. 267–358
  4. ^ Thomas Reese, Morris Karnovsky: Fine structural localization of a blood-brain barrier to exogenous peroxidase. In: Journal of Cell Biology 34, 1967. pp. 207-217
  5. ^ Brightman, Reese: Junctions between intimately opposed cell membranes in the vertebrate brain. In: Journal of Cell Biology 40, 1969. pp. 648-677