Borrelia lymphocytoma

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Classification according to ICD-10
L98.8 Other specified diseases of the skin and subcutaneous tissue
ICD-10 online (WHO version 2019)

The cutaneous lymphoid hyperplasia is a hyperplasia of lymphatic cells that like a malignant lymphoma impress. These pseudolymphomas mostly develop reactively, often during the early phase of a Borrelia infection in the area of ​​the tick bite with a light reddish nodular swelling. The disease can also occur after viral infections .

Synonyms are:

  • Lymphadenosis (or adenitis) cutis benigna (LACB) or lymphadenosis benigna cutis (LABC) (Bäfverstedt)
  • (Cutaneous) B-cell pseudolymphoma
  • Baefverstedt syndrome
  • Lymphocytoma
  • Spiegler-Fendt sarcoid
  • Multiple sarcoid
  • Reactive reticulosis
  • Reticular hyperplasia, focal epithelial
  • benign lymphoplasia of the skin

The name Bäfverstedt syndrome refers to the author of a description from 1943, the Swedish dermatologist Bo Bäfverstedt .

Borrelia lymphocytoma on the cheek.

root cause

1/3 of cases by Borrelia caused mostly by Borrelia afzelii, the other cases remain unsolved; Non-infectious causes such as medications or essential oils are rare. Borrelia lymphocytoma usually occurs in stage I of Lyme borreliosis and is associated with erythema chronicum migrans . Stage II, months after a tick bite, has also been described.

Epidemiology

The disease occurs more frequently in children and adolescents and later mainly in women in their 40s – 70s. Age.

Clinical manifestations

Clinically, there are soft, bulging, nodular or grouped swellings of the skin with a blue-red color. The swelling is caused by lymphocytes in the skin. Typically these can be found on the earlobes, neck, armpits, nipples and genital areas. The regional lymph nodes are swollen in a quarter of patients. The skin lesion can be the center of an erythema migran.

Differential diagnosis

In contrast to malignant B-cell lymphomas, Borrelia lymphocytomas contain B and T lymphocytes of polyclonal origin as well as plasma cells with immunoglobulin formation of the kappa and lambda types.

literature

  • B. Bäfverstedt: Lymphadenosis benigna cutis as a symptom of malignant tumors. In: Acta Dermato-Venereologica . Volume 33, Number 3, 1953, pp. 171-180, ISSN  0001-5555 . PMID 13079520 .
  • B. Bäfverstedt: Lymphadenosis benigna cutis (LABC), its nature, course and prognosis. In: Acta dermato-venereologica. Volume 40, 1960, pp. 10-18, ISSN  0001-5555 . PMID 13685837 .
  • K. Mach: Is lymphadenosis benigna cutis (Bäfverstedt) a clinicopathological unity ?. In: Dermatologische Wochenschrift. Volume 151, Number 48, November 1965, pp. 1351-1357, ISSN  0366-8940 . PMID 5888067 .

Individual evidence

  1. ↑ a b Dermis.net
  2. ↑ a b c d e Borreliosis Society
  3. ↑ a b c Entry on Borrelia lymphocytoma in Flexikon , a wiki from DocCheck , accessed on November 26, 2015.
  4. ↑ a b c Encyclopedia Dermatology ( Memento of the original from September 15, 2014 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.enzyklopaedie-dermatologie.de
  5. ^ Roche Lexicon Medicine
  6. ↑ B. BAEFVERSTEDT: About Lymphocytoma. A clinical and pathological anatomical study. In: Acta Dermato-Venereologica. 1943; 23, pp. 1-202.