Butyrylation

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The Butyrylierung is a post-translational modification of proteins .

properties

Butyrylations occur in eukaryotes . In addition to acetylation , propionylation , crotonylation , myristylation and palmitoylation , it is a form of acylation of proteins. The butyrylation takes place on the ε- amino group of lysines . For example, butyrylated proteins in eukaryotes are histones . The butyrylation as well as the propionylation in eukaryotes is probably catalyzed by the enzymes p300 and CREB binding protein , but using butyryl-CoA .

Individual evidence

  1. ↑ a b c d Y. Chen, R. Sprung, Y. Tang, H. Ball, B. Sangras, SC Kim, JR Falck, J. Peng, W. Gu, Y. Zhao: Lysine propionylation and butyrylation are novel post -translational modifications in histones. In: Molecular & cellular proteomics: MCP. Volume 6, number 5, May 2007, pp. 812-819, doi : 10.1074 / mcp.M700021-MCP200 , PMID 17267393 , PMC 2911958 (free full text).
  2. ^ BR Sabari, D. Zhang, CD Allis, Y. Zhao: Metabolic regulation of gene expression through histone acylations. In: Nature reviews. Molecular cell biology. Volume 18, number 2, 02 2017, pp. 90-101, doi : 10.1038 / nrm.2016.140 , PMID 27924077 , PMC 5320945 (free full text).
  3. ^ S. Zhao, X. Zhang, H. Li: Beyond histone acetylation-writing and erasing histone acylations. In: Current opinion in structural biology. Volume 53, 12 2018, pp. 169–177, doi : 10.1016 / j.sbi.2018.10.001 , PMID 30391813 .
  4. ^ S. Liu, W. Chang, Y. Jin, C. Feng, S. Wu, J. He, T. Xu: The function of histone acetylation in cervical cancer development. In: Bioscience Reports . Volume 39, number 4, April 2019, p., Doi : 10.1042 / BSR20190527 , PMID 30886064 , PMC 6465204 (free full text).
  5. ^ S. Lee: Post-translational modification of proteins in toxicological research: focus on lysine acylation. In: Toxicological research. Volume 29, number 2, June 2013, pp. 81–86, doi : 10.5487 / TR.2013.29.2.081 , PMID 24278632 , PMC 3834447 (free full text).