C-AMP-GMP

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c-AMP-GMP (cyclic adenosine monophosphate guanosine monophosphate) is a cyclized dinucleotide and a second messenger in some bacteria .

properties

c-AMP-GMP forms a ring with two ribose units and two phosphate groups . It occurs in delta proteobacteria . It binds to the c-AMP-GMP riboswitch , which controls , among other things, chemotaxis and genes for the use of iron (III) oxide for the exoelectrogenesis of certain bacteria. C-AMP-GMP presumably controls the gene expression of a single superregulon in delta proteobacteria. c-AMP-GMP is also important for the virulence of Vibrio cholerae .

literature

C. Wang, M. Sinn, J. Stifel, AC Heiler, A. Sommershof, JS Hartig: Synthesis of All Possible Canonical (3'-5'-Linked) Cyclic Dinucleotides and Evaluation of Riboswitch Interactions and Immune-Stimulatory Effects. In: Journal of the American Chemical Society . Volume 139, number 45, 11 2017, pp. 16154-16160, doi : 10.1021 / jacs.7b06141 , PMID 29056046 .

Individual evidence

↑ ^a ^b ^c ^d ^e ^f J. W. Nelson, N. Sudarsan, GE Phillips, S. Stav, CE Lünse, PJ McCown, RR Breaker: Control of bacterial exoelectrogenesis by c-AMP-GMP. In: Proceedings of the National Academy of Sciences . Volume 112, number 17, April 2015, pp. 5389-5394, doi : 10.1073 / pnas.1419264112 , PMID 25848023 , PMC 4418907 (free full text).