C1q nephropathy
The C1q nephropathy is a rare disease of the renal corpuscle , which occurs primarily in children and young adults with an average age from 10.2 to 24.2 years. Diagnosis is by histological examination of a tissue sample from the kidney asked if, in the immunohistochemical study deposits of C1q complement component detected in the glomeruli. C1q nephropathy is a controversial diagnostic entity . The term was first used in 1985 by Jenette and Hipp to describe 15 patients with predominant or predominant deposition of C1q in the renal corpuscles. The urine examination of patients with C1q nephropathy reveals a wide spectrum, ranging from asymptomatic changes in the urine to severe proteinuria and nephrotic syndrome . A hematuria may be absent or be present. In the histological examination there are glomerular minimal changes , a mesangial proliferative glomerulonephritis or focal sclerosis . Proteinuria responds poorly to treatment with corticosteroids and immunosuppressants . In the course of the disease, minimal change glomerulonephritis can turn into focal sclerosis . In patients with minimal change glomerulonephritis, the prognosis is favorable and kidney function usually remains stable. For patients with proliferative glomerulonephritis and focal sclerosis, the prognosis is poorer and a deterioration in renal function must be expected. In individual cases, the C1q deposits can disappear over time.
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Review articles
- Satoshi Hisano, Yuko Fukuma, Yoshie Segawa, Kazuhiko Niimi, Yoshitsugu Kaku, Ken Hatae, Takao Saitoh, Morishige Takeshita, Hiroshi Iwasaki: Clinicopathologic correlation and outcome of C1q nephropathy . In: Clinical Journal of the American Society of Nephrology . tape 3 , no. 6 , November 2008, ISSN 1555-905X , p. 1637-1643 , doi : 10.2215 / CJN.00830208 , PMID 18650410 .
- Alenka Vizjak; Dusan Ferluga, Mojca Rozic, Anastazija Hvala, Jelka Lindic, Tanja Kersnik Levart, Vesna Jurcić, J Charles Jennette: Pathology, clinical presentations, and outcomes of C1q nephropathy . In: Journal of the American Society of Nephrology . tape 19 , no. November 11 , 2008, ISSN 1533-3450 , p. 2237-2244 , doi : 10.1681 / ASN.2007080929 , PMID 18650484 .
- Agnes Fogo: C1q Nephropathy , in Atlas of Renal Pathology, 1999, Am J Kidney Dis . 33 (5) Entry online
Individual evidence
- ↑ JC Jennette, CG Hipp: C1q nephropathy: a distinct pathologic entity usually causing nephrotic syndrome . In: American Journal of Kidney Diseases . tape 6 , no. 2 , August 1985, ISSN 0272-6386 , p. 103-110 , PMID 3875286 .
- ↑ JC Jennette, CG Hipp: Immunohistopathological evaluation of C1q in 800 renal biopsy specimens . In: American Journal of Clinical Pathology . tape 83 , no. 4 , April 1985, ISSN 0002-9173 , pp. 415-420 , PMID 3885712 .
- ↑ Yuko Fukuma, Satoshi Hisano, Yoshie Segawa, Kazuhiko Niimi, Noboru Tsuru, Yoshitsugu Kaku, Ken Hatae, Yasuhiro Kiyoshi, Akihisa Mitsudome, Hiroshi Iwasaki: Clinicopathologic correlation of C1q nephropathy in children . In: American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation . tape 47 , no. 3 , March 2006, ISSN 1523-6838 , p. 412-418 , doi : 10.1053 / j.ajkd.2005.11.013 , PMID 16490619 .
- ^ SS Iskandar MC Browning, WB Lorentz: C1q nephropathy: a pediatric clinicopathologic study . In: American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation . tape 18 , no. 4 , October 1991, ISSN 0272-6386 , p. 459-465 , PMID 1928065 .
- ↑ Glen S Markowitz, Joshua A Schwimmer, M Barry Stokes, Samih Nasr, Robert L Seigle, Anthony M Valeri, Vivette D D'Agati: C1q nephropathy: a variant of focal segmental glomerulosclerosis . In: Kidney International . tape 64 , no. 4 , October 2003, ISSN 0085-2538 , p. 1232-1240 , doi : 10.1046 / j.1523-1755.2003.00218.x , PMID 12969141 .
