CCL1

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CCL1
other names
  • Chemokine (CC Motif) ligand 1
  • T Lymphocyte-Secreted Protein I-309
  • SCYA1
  • Small Inducible Cytokine A1 (I-309, Homologous To Mouse Tca-3)
  • Inflammatory Cytokine I-309
  • I-309
  • P500
  • SISe
  • TCA3

Existing structural data : 1EL0 , 4OIJ , 4OIK

Properties of human protein
Mass / length primary structure 96 amino acids, 10992 Da
Identifier
Gene names CCL1 P500; SISe; TCA3; I-309; SCYA1
External IDs
Orthologue
human House mouse
Entrez 6346 20290
Ensemble ENSG00000108702 ENSMUSG00000020702
UniProt P22362 P10146
Refseq (mRNA) NM_002981 NM_011329
Refseq (protein) NP_002972 NP_035459
Gene locus Chr 17: 34.36 - 34.36 Mb Chr 11: 82.18 - 82.18 Mb
PubMed search 6346 20290

CCL1 ( English CC-chemokine ligand 1 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL1 is involved in inflammatory processes. It binds to CCR8 and is chemotactic for various immune cells , including monocytes , NK cells , immature B cells, and dendritic cells .

Individual evidence

  1. ^ Miller MD, Krangel MS: The human cytokine I-309 is a monocyte chemoattractant . In: Proc. Natl. Acad. Sci. USA . 89, No. 7, April 1992, pp. 2950-4. doi : 10.1073 / pnas.89.7.2950 . PMID 1557400 . PMC 48781 (free full text).
  2. ↑ Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B: Identification of CCR8, the receptor for the human CC chemokine I-309 . In: J. Biol. Chem. . 272, No. 28, July 1997, pp. 17251-4. doi : 10.1074 / jbc.272.28.17251 . PMID 9211859 .