CCL9

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CCL9 ( English CC-chemokine ligand 9 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL9 is involved in inflammatory processes. It is caused by lymph follicle- associated tissue such as B. formed around Peyer's plaques and binds dendritic cells via their integrin alpha M (synonym CD11b ) and the chemokine receptor CCR1 . CCL9 activates osteoclasts through their CCR1 receptor. CCL9 is constitutively produced by macrophages and myeloid cells. CCL9 was also known as CCL10.

Individual evidence

  1. ↑ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A: CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b + dendritic cells . In: J Immunol . 171, No. 6, 2003, pp. 2797-803. doi : 10.4049 / jimmunol.171.6.2797 . PMID 12960300 .
  2. ↑ Lean J, Murphy C, Fuller K, Chambers T: CCL9 / MIP-1gamma and its receptor CCR1 are the major chemokine ligand / receptor species expressed by osteoclasts . In: J Cell Biochem . 87, No. 4, 2002, pp. 386-93. doi : 10.1002 / jcb.10319 . PMID 12397598 .
  3. ↑ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B: A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors . In: J Immunol . 155, No. 5, 1995, pp. 2661-7. PMID 7650394 .
  4. ↑ Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A: Molecular cloning and functional characterization of a novel member of the CC chemokine family . In: J Immunol . 155, No. 11, 1995, pp. 5352-8. PMID 7594550 .