CCL12
| CC motif chemokine 12 | ||
|---|---|---|
| other names |
MCP-1-related chemokine, Monocyte chemoattractant protein 5, Monocyte chemotactic protein 5, MCP-5 |
|
| Mass / length primary structure | 104 amino acids , 11,659 Da | |
| Identifier | ||
| External IDs | ||
CC motif chemokine 12 (CCL12) is a protein from the group of chemokines in rats and mice .
properties
CCL12 is produced in the lymph nodes and the thymus . It is chemoattractive to eosinophils , monocytes, and lymphocytes , but not to neutrophils . CCL12 binds to CCR2 and is involved in allergy and pathogen defense . CCL12 has two disulfide bridges . Its gene is on chromosome 11 in mice .
Web links
Individual evidence
- ↑ a b Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J: Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation . In: J Exp Med . 184, No. 5, 1996, pp. 1939-51. doi : 10.1084 / jem.184.5.1939 . PMID 8920881 . PMC 2192876 (free full text).
- ↑ a b Sarafi M, Garcia-Zepeda E, J MacLean, Charo I, Luster A: Murine monocyte chemoattractant protein (MCP) -5: a novel CC chemokine did is a structural and functional homologue of human MCP-1 . In: J Exp Med . 185, No. 1, 1997, pp. 99-109. doi : 10.1084 / jem.185.1.99 . PMID 8996246 . PMC 2196097 (free full text).