CCR2

from Wikipedia, the free encyclopedia
CC chemokine receptor type 2
CC chemokine receptor type 2
according to PDB  1KAD
other names

Monocyte chemoattractant protein 1 receptor, MCP-1-R

Existing structure data : PDB  1KP1 , PDB  2MLO

Properties of human protein
Mass / length primary structure 374 amino acids , 41,915 Da
Identifier
External IDs
Orthologue (human)
Entrez 729230
Ensemble ENSG00000121807
UniProt P41597
Refseq (mRNA) NM_001123041.2
Refseq (protein) NP_001116513.2
PubMed search 729230

CCR2 ( CC chemokine receptor type 2 ) is a surface protein from the group of chemokine receptors .

properties

CCR2 is expressed by monocytes and IL-12 -activated NK cells . It is the receptor for CCL2 , CCL7 and CCL13 as well as beta-defensin . After binding of CCL2 chemotaxis is initiated via the PI3K , the small G-protein Rac and the protuberance of the lamellipodia . CCR2 is glycosylated , phosphorylated and sulfated .

CCR2 is involved in the development of some neurological diseases, autoimmune diseases , metabolic syndromes and arteriosclerosis .

Web links

Individual evidence

  1. ↑ T. O'Connor, L. Borsig, M. Heikenwalder: CCL2-CCR2 Signaling in Disease Pathogenesis. In: Endocrine, metabolic & immune disorders drug targets. Volume 15, Number 2, 2015, pp. 105-118, PMID 25772168 .