CCL7

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undefined
CCL7
CCL7
according to PDB  1BO0
other names
  • Chemokine (CC Motif) ligand 7
  • Monocyte Chemoattractant Protein 3
  • SCYA7
  • MCP3
  • Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3)
  • SCYA6
  • NC28
  • MARC
  • FIC

Existing structure data : 1BO0 , 1NCV

Properties of human protein
Mass / length primary structure 99 amino acids, 11200 Da
Identifier
External IDs

CCL7 ( English CC-chemokine ligand 7 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL7 is involved in inflammatory processes. It is made by monocytes and some tumor cell lines. CCL7 and CCL2 (synonymous MCP1) have the greatest homology . CCL7 binds to the matrix metalloprotease MMP2 .

Individual evidence

  1. ↑ Opdenakker G, Fiten P, Nys G, Froyen G, Van Roy N, Speleman F, Laureys G, Van Damme J: The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the CC chemokine gene cluster on chromosome 17q11.2-q12 . In: Genomics . 21, No. 2, 1994, pp. 403-8. doi : 10.1006 / geno.1994.1283 . PMID 7916328 .
  2. ↑ Opdenakker G, Froyen G, Fiten P, Proost P, Van Damme J: Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines . In: Biochem. Biophys. Res. Commun. . 191, No. 2, 1993, pp. 535-42. doi : 10.1006 / bbrc.1993.1251 . PMID 8461011 .
  3. ↑ GA McQuibban, JH Gong. EM Tam, CA McCulloch, I. Clark-Lewis, CM Overall: Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3 . In: Science . 289, No. 5482, UNITED STATES, August 2000, pp. 1202-6. doi : 10.1126 / science.289.5482.1202 . PMID 10947989 .