CCL2

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CCL2
CCL2
according to PDB  1DOK
other names
  • Chemokine (CC Motif) ligand 2
  • Monocyte Chemotactic And Activating Factor
  • Monocyte Chemotactic Protein 1
  • Monocyte Secretory Protein JE
  • SCYA2
  • MCAF
  • MCP1
  • Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je)
  • Monocyte Chemoattractant Protein-1
  • HSMCR30
  • GDCF-2
  • SMC-CF

Existing structure data : 1DOK , 1DOL , 1DOM , 1DON , 1MCA , 1ML0

Properties of human protein
Mass / length primary structure 99 amino acids, 11025 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 6347 20293
UniProt P13500 Q62401
PubMed search 6347 20293

CCL2 ( English CC chemokine ligand 2 , CC chemokine ligand 2 ') is a cytokine from the family of CC chemokines . Synonyms for the CCL2 are monocyte chemotactic protein 1 (MCP1) and small inducible cytokine A2 .

properties

CCL2 is formed at sites of inflammation by monocytes , T memory cells and dendritic cells , secreted , bound to proteoglycans of endothelial cells , activated proteolytically by matrix metalloprotease 12 ( MMP-12 ) and then binds these cell types there. CCL2 is also made by neurons , astrocytes, and microglia . The gene expression of CCL2 is mainly in the cerebral cortex , in the globus pallidus , in the hippocampus , in the paraventricular and supraoptic hypothalamic nuclei, in the substantia nigra , in the nucleus motorius nervi facialis , in the trigeminal motor and spinal nuclei, in the gigantocellular reticular nucleus the Purkinje cells of the cerebellum .

CCL2 is bound by the CCR2 and CCR4 receptors . After stimulating cells with CCL2, the gene expression of MCPIP1 is induced.

Individual evidence

  1. ^ Carr MW, Roth SJ, Luther E, Rose SS, Springer TA: Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant . In: Proceedings of the National Academy of Sciences . 91, No. 9, April 1994, pp. 3652-6. doi : 10.1073 / pnas.91.9.3652 . PMID 8170963 . PMC 43639 (free full text).
  2. ↑ Xu LL, Warren MK, Rose WL, Gong W, Wang JM: Human recombinant monocyte chemotactic protein and other CC chemokines bind and induce directional migration of dendritic cells in vitro . In: Journal of Leukocyte Biology . 60, No. 3, September 1996, pp. 365-71. PMID 8830793 .
  3. ↑ Yoshimura T, Yuhki N, Moore SK, Appella E, Lerman MI, Leonard EJ: Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE . In: FEBS Letters . 244, No. 2, February 1989, pp. 487-93. doi : 10.1016 / 0014-5793 (89) 80590-3 . PMID 2465924 .
  4. ↑ Furutani Y, Nomura H, Notake M, Oyamada Y, Fukui T, Yamada M, Larsen CG, Oppenheim JJ, Matsushima K: Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF) . In: Biochemical and Biophysical Research Communications . 159, No. 1, February 1989, pp. 249-55. doi : 10.1016 / 0006-291X (89) 92430-3 . PMID 2923622 .
  5. ↑ Banisadr G, Gosselin RD, Mechighel P, Kitabgi P, Rostène W, Parsadaniantz SM: Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1 / CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides . In: The Journal of Comparative Neurology . 489, No. 3, August 2005, pp. 275-92. doi : 10.1002 / cne.20598 . PMID 16025454 .
  6. ↑ Craig MJ, Loberg RD: CCL2 (Monocyte Chemoattractant Protein-1) in cancer bone metastases . In: Cancer Metastasis Reviews . 25, No. 4, December 2006, pp. 611-9. doi : 10.1007 / s10555-006-9027-x . PMID 17160712 .