CCR4

CC chemokine receptor type 4
other names	K5-5, CD antigen CD194
Properties of human protein
Mass / length primary structure	360 amino acids , 41,403 Da
Identifier
External IDs	GeneCards : CCR4 ; OMIM : 604836 ; UniProt : P51679 ;
	Orthologue (human)
Entrez	1233
Ensemble	ENSG00000183813
UniProt	P51679
Refseq (mRNA)	NM_005508.4
Refseq (protein)	NP_005499.1
PubMed search	1233

CC chemokine receptor type 4 (CCR4) is a surface protein from the group of chemokine receptors .

properties

CCR4 is a G-protein-coupled receptor and is formed by cells of the thymus , in peripheral leukocytes (mainly CD4 -positive cells), in basophils and thrombocytes as well as in endothelial cells of the vessels of the brain and the heart, in smaller amounts also in macrophages , Interleukin-2 -activated NK cells and memory T cells of the skin (especially when they produce CLA ). It binds CC-type chemokines , including MIP-1β , RANTES , MCP-1 , CCL17 / TARC, CCL22 / MDC and CKLF isoform 1 / CKLF1 . After activation, G (i) proteins cause signal transduction via the second messenger phosphatidylinositol and calcium ions . CCR4 binds memory T cells. CCR4 is a co-receptor for some HIV- 2 isolates. CCR4 has disulfide bridges and is phosphorylated and glycosylated .

The humanized monoclonal antibody mogamulizumab binds to CCR4 and is used against cutaneous T-cell lymphoma .