CCL22

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CCL22
other names
  • Chemokine (CC Motif) ligand 22
  • SCYA22
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22
  • Stimulated T-Cell Chemotactic Protein 1
  • Macrophage-Derived Chemokines
  • CC Chemokine STCP-1
  • MDC (1-69)
  • A-152E5.1
  • DC / B-CK
  • ABCD-1
Properties of human protein
Mass / length primary structure 93 amino acids, 10625 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 6367 20299
UniProt O00626 O88430
PubMed search 6367 20299

CCL22 ( English CC chemokine ligand 22 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL22 is involved in inflammatory processes. It binds to CCR4 . CCL22 is produced by macrophages and dendritic cells and binds dendritic cells and TH2 cells. It is induced by the cytokines interleukin-4 and interleukin-5 and downregulated by interferon-gamma . CCL22 is implicated in TH2 hypersensitivity of the airways and in atopic dermatitis.

Individual evidence

  1. ↑ M. Vulcano, C. Albanesi, A. Stoppacciaro, R. Bagnati, G. D'Amico, S. Struyf, P. Transidico, R. Bonecchi, A. Del Prete, P. Allavena, LP Ruco, C. Chiabrando , G. Girolomoni, A. Mantovani, S. Sozzani: Dendritic cells as a major source of macrophage-derived chemokine / CCL22 in vitro and in vivo. In: European Journal of Immunology. Volume 31, number 3, March 2001, pp. 812-822, doi : 10.1002 / 1521-4141 (200103) 31: 3 <812 :: AID-IMMU812> 3.0.CO; 2-L , PMID 11241286 .
  2. ↑ a b c U. Yamashita, E. Kuroda: Regulation of macrophage-derived chemokine (MDC, CCL22) production. In: Critical reviews in immunology. Volume 22, Number 2, 2002, pp. 105-114, PMID 12433129 .