MIP-1β
CCL4 | ||
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according to PDB 1HUM | ||
other names |
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Existing structural data : 1HUM , 1HUN , 1JE4 , 2FFK , 2FIN , 2X6L |
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Properties of human protein | ||
Mass / length primary structure | 92 amino acids, 10212 Da | |
Identifier | ||
External IDs | ||
Orthologue | ||
human | House mouse | |
Entrez | 6351 | 20303 |
UniProt | P13236 | P14097 |
PubMed search | 6351 |
20303
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MIP-1β (synonym CCL4 , English CC chemokine ligand 4 ) is a cytokine from the family of CC chemokines .
properties
CCL4 binds to the coreceptor of HIV- 1, CCR5 , and thereby competitively inhibits the infection of cells with HIV-1 . CCL4 is the major HIV-inhibiting factor of cytotoxic T cells . CCL4 is mainly formed by cytotoxic T cells with a low perforin content. CCL4 binds to CCL3 . It also binds to CCR1 and CCR2 isoform B.
Individual evidence
- ↑ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC , Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8 + T cells . In: Science . 270, No. 5243, December 1995, pp. 1811-5. doi : 10.1126 / science.270.5243.1811 . PMID 8525373 .
- ↑ Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK: Perforin-low memory CD8 + cells are the predominant T cells in normal humans that synthesize the β-chemokine macrophage inflammatory protein-1β . In: Proc. Natl. Acad. Sci. USA . 98, No. 16, July 2001, pp. 9283-8. doi : 10.1073 / pnas.161298998 . PMID 11470920 . PMC 55412 (free full text).
- ↑ E. Guan, J. Wang, MA Norcross: Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer . In: J. Biol. Chem. . 276, No. 15, United States, April 2001, ISSN 0021-9258 , pp. 12404-9. doi : 10.1074 / jbc.M006327200 . PMID 11278300 .
- ↑ MIP-1β. In: GeneCards (English).