CCL13

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CCL13
other names
  • Chemokine (CC Motif) ligand 13
  • SCYA13
  • NCC1
  • Small Inducible Cytokine Subfamily A (Cys-Cys), Member 13
  • Monocyte Chemoattractant Protein 4
  • Monocyte Chemotactic Protein 4
  • Small-Inducible Cytokines A13
  • CK beta 10
  • MCP-4
  • NCC-1
  • CKb10
  • SCYL1

Existing structural data : 2RA4

Properties of human protein
Mass / length primary structure 98 amino acids, 10986 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 6357 20296
UniProt Q99616 P10148
PubMed search 6357 20296

CCL13 ( English CC chemokine ligand 13 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL8 is involved in inflammatory processes. It is chemotactic for and activates various immune cells including monocytes , eosinophils , T lymphocytes and basophils by binding to CCR2 , CCR3 and CCR5 . CCL13 is involved in the development of asthma . CCL13 is induced by the cytokines interleukin-1 and TNF-α .

Individual evidence

  1. ↑ Blanpain et al., CCR5 binds multiple CC chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94: 1899-905.
  2. ↑ Lamkhioued et al., Monocyte chemoattractant protein (MCP) -4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162: 723-32.