CCL27

CCL27
other names	Chemokine (CC Motif) ligand 27 CC Chemokine ILC SCYA27 CTACK ILC Small Inducible Cytokine Subfamily A (Cys-Cys), Member 27 Cutaneous T-Cell Attracting Chemokines IL-11 R-alpha chemokine locus Skinkine ESKINE PESKY CTAK ALP
Existing structural data : 2KUM
Properties of human protein
Mass / length primary structure	112 amino acids, 12618 Da
Identifier
External IDs	GeneCards :  CCL27 OMIM :  604833 UniProt :  Q9Y4X3
Orthologue
	human	House mouse
Entrez	10850	100861978
UniProt	Q9Y4X3	Q9Z1X0
PubMed search	10850	100861978

CCL27 ( English CC chemokine ligand 27 ) is a cytokine belonging to the family of the C-C chemokines .

properties

CCL27 is involved in inflammatory processes. It is chemotactic for memory T cells and binds them via the CCR10 receptor in the skin, among other things . CCL27 is produced in the gonads , thymus , placenta, and skin.

Individual evidence

1. ↑ Homey et al. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK / ALP / ILC). J. Immunol. 164: 3465-3470, 2000.
2. ↑ Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. USA 96: 14470-14475, 1999.
3. ↑ Homey et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nature Med. 8: 157-165, 2002.