CCL5
CCL5 | ||
---|---|---|
according to PDB 1EQT | ||
other names |
|
|
Existing structural data : 1B3A , 1EQT , 1HRJ , 1RTN , 1RTO , 1U4L |
||
Properties of human protein | ||
Mass / length primary structure | 91 amino acids, 9990 Da | |
Identifier | ||
External IDs | ||
Orthologue | ||
human | House mouse | |
Entrez | 6352 | 20304 |
UniProt | P13501 | P30882 |
PubMed search | 6352 |
20304
|
CCL5 ( English CC-chemokine ligand 5 ) is a cytokine belonging to the family of the C-C chemokines .
properties
CCL5 is involved in inflammatory processes. CCL5 is produced by cytotoxic T cells and binds T cells , monocytes and eosinophils by binding the receptors CCR3 , CCR5 and CCR1 . CCL5 activates the GPCR GPR75 .
CCL5 is involved in the defense against infections with HIV- 1 because it competitively inhibits the binding of HIV to its coreceptor CCR5 .
Individual evidence
- ↑ Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS: Cloning, expression, and characterization of the human eosinophil eotaxin receptor . In: J. Med.. . 183, No. 5, May 1996, pp. 2349-54. doi : 10.1084 / jem.183.5.2349 . PMID 8642344 . PMC 2192548 (free full text).
- ↑ a b c Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J: Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils . In: Eur. J. Immunol. . 31, No. 7, July 2001, pp. 2170-8. doi : 10.1002 / 1521-4141 (200107) 31: 7 <2170 :: AID-IMMU2170> 3.0.CO; 2-D . PMID 11449371 .
- ↑ Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L: Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages . In: Biochim. Biophys. Acta . 1617, No. 1-2, October 2003, pp. 80-8. doi : 10.1016 / j.bbamem.2003.09.006 . PMID 14637022 .
- ↑ a b Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A , Marchant D, Clapham PR, Wells TN: The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity . In: J. Biol. Chem. . 276, No. 14, April 2001, pp. 10620-6. doi : 10.1074 / jbc.M010867200 . PMID 11116158 .
- ↑ Ignatov A, Robert J, Gregory-Evans C, Schaller HC: RANTES stimulates Ca2 + mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75 . In: Br. J. Pharmacol. . 149, No. 5, November 2006, pp. 490-7. doi : 10.1038 / sj.bjp.0706909 . PMID 17001303 . PMC 2014681 (free full text).
- ↑ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8 + T cells . In: Science . 270, No. 5243, December 1995, pp. 1811-5. doi : 10.1126 / science.270.5243.1811 . PMID 8525373 .