CD79b

B-cell antigen receptor complex-associated protein beta chain
other names	B-cell-specific glycoprotein B29, Ig-beta, immunoglobulin-associated B29 protein, CD79b
	Existing structural data : PDB 3KG5
Properties of human protein
Mass / length primary structure	229 amino acids , 26,048 Da
Identifier
External IDs	GeneCards : CD79B ; OMIM : 147245 ; UniProt : P40259 ;
	Orthologue (human)
Entrez	974
Ensemble	ENSG00000007312
UniProt	P40259
Refseq (mRNA)	NM_000626.3
Refseq (protein)	NP_000617.1
PubMed search	974

CD79b (synonymous with B-cell antigen receptor complex -associated protein β-chain ) is a surface protein and is involved in the humoral immune response .

properties

CD79b is produced by B cells . It binds to CD79a and is connected to it by disulfide bridges . Two of these heterodimers bind to membrane-bound antibodies of the subtypes m IgM or m IgD and thus form the B-cell receptor (BCR) to which antigens bind. CD79b enhances the phosphorylation of CD79a. Following antigen binding, the antigen-antibody BCR is endocytosed . CD79b is glycosylated . It has an intracellular ITAM motif which, after activation of the BCR, binds the protein kinases Syk or Lyn and is phosphorylated by them.

Certain CD79b genetic defects are associated with some form of agammaglobulinaemia .

Web links

MeSH CD79b

Individual evidence

↑ Louis B. Justement: Signal Transduction and the Coordination of B Lymphocyte Development and Function I. Springer Science & Business Media, 2012, ISBN 978-3-642-57066-7 , pp. 4–12.
^ V. Seda, M. Mraz: B-cell receptor signaling and its crosstalk with other pathways in normal and malignant cells. In: European journal of haematology. Volume 94, number 3, March 2015, pp. 193-205, doi : 10.1111 / ejh.12427 , PMID 25080849 .
^ Heizmann B, Reth M, Infantino S: Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor . In: Proceedings of the National Academy of Sciences . 107, No. 43, October 2010, pp. 18563-8. doi : 10.1073 / pnas.1009048107 . PMID 20940318 . PMC 2972992 (free full text).

[Justement-1] Louis B. Justement: Signal Transduction and the Coordination of B Lymphocyte Development and Function I. Springer Science & Business Media, 2012, ISBN 978-3-642-57066-7 , pp. 4–12.

[2] V. Seda, M. Mraz: B-cell receptor signaling and its crosstalk with other pathways in normal and malignant cells. In: European journal of haematology. Volume 94, number 3, March 2015, pp. 193-205, doi : 10.1111 / ejh.12427 , PMID 25080849 .

[pmid20940318-3] Heizmann B, Reth M, Infantino S: Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor . In: Proceedings of the National Academy of Sciences . 107, No. 43, October 2010, pp. 18563-8. doi : 10.1073 / pnas.1009048107 . PMID 20940318 . PMC 2972992 (free full text).