CSK 4 motif

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The CSK 4 motif is a structural motif of proteins .

properties

The CSK 4 motif consists of the amino acid sequence Cys - Ser - Lys -Lys-Lys-Lys (short: CSKKKK). Triple palmitoylated (Pam3) CSK 4 motifs are bound by TLR-2 and activate the innate immune response . The first palmitoylation on CSK 4 takes place at the N terminus (with Pam-CSK 4 ), with Pam2-CSK 4 both palmitic acids are bound to the sulfur atom of the side chain of the cysteine via a diacylglyceride and with Pam3-CSK 4 there is a palmitoylation on all three before named positions.

Individual evidence

  1. ↑ DW Park, JH Lyu, JS Kim, H. Chin, YS Bae, SH Baek: Role of JAK2-STAT3 in TLR2-mediated tissue factor expression. In: Journal of cellular biochemistry. Volume 114, Number 6, June 2013, pp. 1315-1321, doi : 10.1002 / jcb.24472 , PMID 23238822 .
  2. ^ IW Hamley: Lipopeptides: from self-assembly to bioactivity. In: Chemical communications. Volume 51, Number 41, May 2015, pp. 8574-8583, doi : 10.1039 / c5cc01535a , PMID 25797909 .