KK-LC-1

Kita-kyushu lung cancer antigen 1
other names	Cancer / testis antigen 83, KK-LC-1
Properties of human protein
Mass / length primary structure	113 amino acids , 12,784 Da
Identifier
External IDs	GeneCards : CT83 ; OMIM : 300625 ; UniProt : Q5H943 ;
	Orthologue (human)
Entrez	203413
Ensemble	ENSG00000204019
UniProt	Q5H943 ;
PubMed search	203413

KK-LC-1 (from Kita-kyushu lung cancer antigen 1 ), also Cancer / testis antigen 83 , CT83 , CXorf61 , is a protein and tumor antigen from the group of the Cancer / Testis antigens .

properties

KK-LC-1 is 113 amino acids long and has a mass of 12,784 Da . It is N -glycosylated at position 83 . KK-LC-1 is used as tumor antigen hardly in normal cells before (except in immune privileged spermatocytes ), but often in different tumors expressing such. B. non-small cell lung cancers . KK-LC-1 is a target antigen in the development of cancer vaccines and cancer immunotherapies using adoptive cell transfer .

Individual evidence

↑ T. Baba, H. Shiota, K. Kuroda, Y. Shigematsu, Y. Ichiki, H. Uramoto, T. Hanagiri, F. Tanaka: Cancer / testis antigen expression as a predictor for epidermal growth factor receptor mutation and prognosis in lung adenocarcinoma. In: European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery. Volume 43, Number 4, April 2013, pp. 759-764, doi : 10.1093 / ejcts / ezs426 , PMID 22826471 .
↑ T. Fukuyama, T. Hanagiri, M. Takenoyama, Y. Ichiki, M. Mizukami, T. So, M. Sugaya, T. So, K. Sugio, K. Yasumoto: Identification of a new cancer / germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma. In: Cancer Research . Volume 66, Number 9, May 2006, pp. 4922-4928, doi : 10.1158 / 0008-5472.CAN-05-3840 , PMID 16651449 .
↑ Y. Shigematsu, T. Hanagiri, H. Shiota, K. Kuroda, T. Baba, M. Mizukami, T. So, Y. Ichiki, M. Yasuda, T. So, M. Takenoyama, K. Yasumoto: Clinical Significance of cancer / testis antigens expression in patients with non-small cell lung cancer. In: Lung cancer (Amsterdam, Netherlands). Volume 68, Number 1, April 2010, pp. 105-110, doi : 10.1016 / j.lungcan.2009.05.010 , PMID 19545928 .

[1] T. Baba, H. Shiota, K. Kuroda, Y. Shigematsu, Y. Ichiki, H. Uramoto, T. Hanagiri, F. Tanaka: Cancer / testis antigen expression as a predictor for epidermal growth factor receptor mutation and prognosis in lung adenocarcinoma. In: European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery. Volume 43, Number 4, April 2013, pp. 759-764, doi : 10.1093 / ejcts / ezs426 , PMID 22826471 .

[2] T. Fukuyama, T. Hanagiri, M. Takenoyama, Y. Ichiki, M. Mizukami, T. So, M. Sugaya, T. So, K. Sugio, K. Yasumoto: Identification of a new cancer / germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma. In: Cancer Research . Volume 66, Number 9, May 2006, pp. 4922-4928, doi : 10.1158 / 0008-5472.CAN-05-3840 , PMID 16651449 .

[3] Y. Shigematsu, T. Hanagiri, H. Shiota, K. Kuroda, T. Baba, M. Mizukami, T. So, Y. Ichiki, M. Yasuda, T. So, M. Takenoyama, K. Yasumoto: Clinical Significance of cancer / testis antigens expression in patients with non-small cell lung cancer. In: Lung cancer (Amsterdam, Netherlands). Volume 68, Number 1, April 2010, pp. 105-110, doi : 10.1016 / j.lungcan.2009.05.010 , PMID 19545928 .