CXCL1

CXCL1
	according to PDB 1MGS
other names	Chemokine (CXC Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha); GRO1 Oncogene (Melanoma Growth Stimulating Activity, Alpha); Neutrophil-Activating Protein 3; Fibroblast Secretory Protein; GRO-Alpha (1-73); NAP-3; SCYB1; GRO1; MGSA Alpha; FSP;
	Existing structural data : 1MGS , 1MSG , 1MSH , 1ROD
Properties of human protein
Mass / length primary structure	107 amino acids, 11301 Da
Identifier
External IDs	GeneCards : CXCL1 ; OMIM : 155730 ; UniProt : P09341 ;

CXCL1 is a cytokine from the CXC chemokine family .

properties

CXCL1 is produced by macrophages , neutrophils and epithelial cells , among others . CXCL1 binds neutrophils to sites of inflammation . CXCL1 is involved in the development of the spinal cord (where it inhibits the migration of oligodendrocyte precursor cells), angiogenesis , inflammation, wound healing and the development of tumors .

CXCL1 is mitogenic and implicated in the pathogenesis of melanoma .

CXCL1 is bound by the CXCR2 receptor . The CXCL1 gene lies in a gene cluster with genes from other CXC chemokines.

Individual evidence

↑ N. Iida, GR Grotendorst: Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue . In: Mol. Cell. Biol . 10, No. 10, October 1990, pp. 5596-5599. PMID 2078213 . PMC 361282 (free full text).
↑ S. Becker, J. Quay, HS Koren, JS Haskill: Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages . In: Am. J. Physiol. . 266, No. 3 Pt 1, March 1994, pp. L278-L286. PMID 8166297 .
^ B. Moser, I. Clark-Lewis, R. Zwahlen, M. Baggiolini: Neutrophil-activating properties of the melanoma growth-stimulatory activity . In: J. Med.. . 171, No. 5, May 1990, pp. 1797-1802. doi : 10.1084 / jem.171.5.1797 . PMID 2185333 . PMC 2187876 (free full text).
↑ C. Schumacher, I. Clark-Lewis, M. Baggiolini, B. Moser: High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils . In: Proc. Natl. Acad. Sci. USA . 89, No. 21, November 1992, pp. 10542-10546. doi : 10.1073 / pnas.89.21.10542 . PMID 1438244 . PMC 50375 (free full text).
↑ ^a ^b H. H. Tsai, E. Frost, V. To, S. Robinson, C. Ffrench-Constant, R. Geertman, RM Ransohoff, RH Miller: The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration . In: Cell . 110, No. 3, August 2002, pp. 373-383. doi : 10.1016 / S0092-8674 (02) 00838-3 . PMID 12176324 .
↑ RM Devalaraja, LB Nanney, J. Du, Q. Qian, Y. Yu, MN Devalaraja, A. Richmond: Delayed wound healing in CXCR2 knockout mice . In: J. Invest. Dermatol. . 115, No. 2, August 2000, pp. 234-244. doi : 10.1046 / j.1523-1747.2000.00034.x . PMID 10951241 . PMC 2664868 (free full text).
↑ H. Haghnegahdar, J. Du, D. Wang, RM Strieter, MD Burdick, LB Nanney, N. Cardwell, J. Luan, R. Shattuck-Brandt, A. Richmond: The tumorigenic and angiogenic effects of MGSA / GRO proteins in melanoma . In: J. Leukoc. Biol . 67, No. 1, January 2000, pp. 53-62. PMID 10647998 . PMC 2669312 (free full text).
↑ JD Owen, R. Strieter, M. Burdick, H. Haghnegahdar, L. Nanney, R. Shattuck-Brandt, A. Richmond: Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity / growth-regulated cytokine beta and gamma proteins . In: Int. J. Cancer . 73, No. 1, September 1997, pp. 94-103. doi : 10.1002 / (SICI) 1097-0215 (19970926) 73: 1 <94 :: AID-IJC15> 3.0.CO; 2-5 . PMID 9334815 .
↑ A. Anisowicz, L. Bardwell, R. Sager: Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells . In: Proc. Natl. Acad. Sci. USA . 84, No. 20, October 1987, pp. 7188-7192. doi : 10.1073 / pnas.84.20.7188 . PMID 2890161 . PMC 299255 (free full text).
^ A. Richmond, HG Thomas: Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution . In: J. Cell. Biochem. . 36, No. 2, February 1988, pp. 185-198. doi : 10.1002 / jcb.240360209 . PMID 3356754 .
↑ A. Richmond, E. Balentien, HG Thomas, G. Flagg, DE Barton, J. Spiess, R. Bordoni, U. Francke, R. Derynck: Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin . In: EMBO J. . 7, No. 7, July 1988, pp. 2025-2033. PMID 2970963 . PMC 454478 (free full text).

[pmid2078213-1] N. Iida, GR Grotendorst: Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue . In: Mol. Cell. Biol . 10, No. 10, October 1990, pp. 5596-5599. PMID 2078213 . PMC 361282 (free full text).

[pmid8166297-2] S. Becker, J. Quay, HS Koren, JS Haskill: Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages . In: Am. J. Physiol. . 266, No. 3 Pt 1, March 1994, pp. L278-L286. PMID 8166297 .

[pmid2185333-3] B. Moser, I. Clark-Lewis, R. Zwahlen, M. Baggiolini: Neutrophil-activating properties of the melanoma growth-stimulatory activity . In: J. Med.. . 171, No. 5, May 1990, pp. 1797-1802. doi : 10.1084 / jem.171.5.1797 . PMID 2185333 . PMC 2187876 (free full text).

[pmid1438244-4] C. Schumacher, I. Clark-Lewis, M. Baggiolini, B. Moser: High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils . In: Proc. Natl. Acad. Sci. USA . 89, No. 21, November 1992, pp. 10542-10546. doi : 10.1073 / pnas.89.21.10542 . PMID 1438244 . PMC 50375 (free full text).

[pmid12176324-5] H. H. Tsai, E. Frost, V. To, S. Robinson, C. Ffrench-Constant, R. Geertman, RM Ransohoff, RH Miller: The chemokine receptor CXCR2 controls positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration . In: Cell . 110, No. 3, August 2002, pp. 373-383. doi : 10.1016 / S0092-8674 (02) 00838-3 . PMID 12176324 .

[pmid10951241-6] RM Devalaraja, LB Nanney, J. Du, Q. Qian, Y. Yu, MN Devalaraja, A. Richmond: Delayed wound healing in CXCR2 knockout mice . In: J. Invest. Dermatol. . 115, No. 2, August 2000, pp. 234-244. doi : 10.1046 / j.1523-1747.2000.00034.x . PMID 10951241 . PMC 2664868 (free full text).

[pmid10647998-7] H. Haghnegahdar, J. Du, D. Wang, RM Strieter, MD Burdick, LB Nanney, N. Cardwell, J. Luan, R. Shattuck-Brandt, A. Richmond: The tumorigenic and angiogenic effects of MGSA / GRO proteins in melanoma . In: J. Leukoc. Biol . 67, No. 1, January 2000, pp. 53-62. PMID 10647998 . PMC 2669312 (free full text).

[pmid9334815-8] JD Owen, R. Strieter, M. Burdick, H. Haghnegahdar, L. Nanney, R. Shattuck-Brandt, A. Richmond: Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity / growth-regulated cytokine beta and gamma proteins . In: Int. J. Cancer . 73, No. 1, September 1997, pp. 94-103. doi : 10.1002 / (SICI) 1097-0215 (19970926) 73: 1 <94 :: AID-IJC15> 3.0.CO; 2-5 . PMID 9334815 .

[pmid2890161-9] A. Anisowicz, L. Bardwell, R. Sager: Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells . In: Proc. Natl. Acad. Sci. USA . 84, No. 20, October 1987, pp. 7188-7192. doi : 10.1073 / pnas.84.20.7188 . PMID 2890161 . PMC 299255 (free full text).

[pmid3356754-10] A. Richmond, HG Thomas: Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution . In: J. Cell. Biochem. . 36, No. 2, February 1988, pp. 185-198. doi : 10.1002 / jcb.240360209 . PMID 3356754 .

[pmid2970963-11] A. Richmond, E. Balentien, HG Thomas, G. Flagg, DE Barton, J. Spiess, R. Bordoni, U. Francke, R. Derynck: Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin . In: EMBO J. . 7, No. 7, July 1988, pp. 2025-2033. PMID 2970963 . PMC 454478 (free full text).