CXCR2
| CXCR2 | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 360 AS ; 40.8 kDa | |
| Secondary to quaternary structure | 7TM | |
| Identifier | ||
| Gene names | CXCR2 , IL-8R B, CDw128b, CD182 | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Vertebrates | |
CXCR2 (short for CXC-motif chemokine receptor 2 , also interleukin-8 receptor beta ( IL-8RB ), GRO / MGSA receptor , CDw128b , CD182 ) is a receptor protein from the chemokine receptor family . CXCR2 occurs particularly on the surface of cells of the immune system , such as neutrophils , for example . This receptor can be stimulated by the chemokines CXCL1 (GRO-α), CXCL2 (GRO-β), CXCL3 (GRO-γ), CXCL5 , CXCL7 and CXCL8 ( interleukin 8) and mediates its effects by activating an intracellular signal transduction cascade at the G i proteins are involved. CXCR2 is believed to play an important role in the development of inflammatory diseases and tumor growth .
Occurrence
CXCR2 can be detected in particular on neutrophils, but also on eosinophils , basophils , dendritic cells , T-lymphocytes and macrophages .
biochemistry
CXCR2 is encoded by a gene on chromosome 2 locus q33-q36.
Structurally, CXCR2 belongs to the group of G protein-coupled receptors . After binding of the chemokines CXCL1, CXCL2, CXCL3, CXCL5, CXCL7 or CXCL8, a signal transduction cascade is activated inside the cell, in which G proteins, Ca 2+ and MAP kinases are involved. The signal transduction cascade also includes activation of integrins and changes in the cytoskeleton. These are prerequisites for a targeted movement ( chemotaxis ) of CXCR2-expressing cells towards a chemokine gradient.
function
CXCR2 plays an important role in the recruitment of leukocytes into the inflamed tissue. In addition, CXCR2 is important in the formation of new blood vessels ( angiogenesis ) involved chemokine receptor. Through this mechanism, CXCR2 can promote tumor growth.
Individual evidence
- ↑ Murphy PM, Baggiolini M, Charo IF, et al : International union of pharmacology. XXII. Nomenclature for chemokine receptors . In: Pharmacol. Rev. . 52, No. 1, March 2000, pp. 145-176. PMID 10699158 .
- ↑ Addison CL, Daniel TO, Burdick MD, et al : The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR + CXC chemokine-induced angiogenic activity . In: J. Immunol. . 165, No. 9, November 2000, pp. 5269-5277. PMID 11046061 .