CXCL2
| CXC motif chemokine 2 | ||
|---|---|---|
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| according to PDB 1QNK | ||
| other names |
Growth-regulated protein beta, Gro-beta |
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| Properties of human protein | ||
| Mass / length primary structure | 107 amino acids , 11,389 Da | |
| Identifier | ||
| External IDs | ||
CXC motif chemokine 2 (CXCL2) is a protein belonging to the chemokine group .
properties
CXCL2 is produced by activated monocytes , macrophages and neutrophils at the site of inflammation and recruits polymorphonuclear leukocytes and haematopoietic stem cells . Amino acids 5 to 73 show a chemoattractive effect on neutrophils. CXCL2 has two disulfide bridges . CXCL2 binds to CXCR1 and CXCR2 . It is formed in response to lipopolysaccharides . It is 90% identical to CXCL1 . In humans, the gene on chromosome 4 is in a gene cluster with other CXC chemokines.
Web links
Individual evidence
- ↑ Wolpe, SD, Sherry, B., Juers, D., Davatelis, G., Yurt RW, Cerami, A . Identification and characterization of macrophage inflammatory protein 2. Proc. Natl. Acad. Sci. 86: 612-616, 1989. PMID 2643119
- ↑ Iida N., Grotendorst GR Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol. Cell. Biol. 10: 5596-5599, 1990. PMID 2078213
- ↑ a b Pelus LM, Fukuda S. Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties. Exp Hematol. 2006 Aug; 34 (8): 1010-20. PMID 16863907
- Jump up ↑ O'Donovan, N., Galvin, M., Morgan, JG Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84: 39-42, 1999. PMID 10343098