Carboxypeptidase B2
| Carboxypeptidase B2 | ||
|---|---|---|
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| according to PDB 3D66 | ||
| other names |
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| Properties of human protein | ||
| Identifier | ||
| Gene names | CPB2 CPU; PCPB; TAFI | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 3.4.17.20 | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 1361 | 56373 |
| Ensemble | ENSG00000080618 | ENSMUSG00000021999 |
| UniProt | Q96IY4 | Q9JHH6 |
| Refseq (mRNA) | NM_001278541 | NM_019775 |
| Refseq (protein) | NP_001265470 | NP_062749 |
| Gene locus | Chr 13: 46.05 - 46.11 Mb | Chr 14: 75.24 - 75.28 Mb |
| PubMed search | 1361 |
56373
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The carboxypeptidase B2 (synonym TAFI , for T hrombin a ktivierbarer F ibrinolyse I nhibitor, carboxypeptidase U , CPU, plasma carboxypeptidase B , pCPB) is a protein in the blood, which is the blood coagulation promoted in which it the dissolution of blood clots ( fibrinolysis inhibits) .
Functions
Blood clotting
When blood clots dissolve ( fibrinolysis ), C -terminal lysine residues are formed which, as part of a positive feedback, significantly increase the activity of plasminogen and tPA . This feedback is limited by TAFI by cleaving off the C-terminal lysine residues. TAFI is activated , among other things, by thrombin (factor II). If the activity of TAFI exceeds a certain limit, it inhibits fibrinolysis. If the activity of TAFI falls below a certain limit value , the C-terminal lysine residues accumulate and thus strong fibrinolysis occurs.
Anti-inflammatory
TAFI also inhibits the activity of complement component C5 , osteopontin and bradykinin which play an important role in inflammatory reactions. TAFI has an anti-inflammatory effect.
Individual evidence
- ^ A b J. H. Foley, PY Kim, NJ Mutch, A. Gils: Insights into thrombin activatable fibrinolysis inhibitor function and regulation. In: Journal of Thrombosis and Haemostasis. 11, 2013, p. 306, doi: 10.1111 / jth.12216 .