Quinazoline alkaloids

Quinazoline , the main body of the quinazoline alkaloids

The quinazoline alkaloids are naturally occurring chemical compounds from the group of alkaloids , which are chemically derived from the quinazoline . Some quinazoline alkaloids show bronchodilator effect and stimulate the breathing . An abortive effect was also found for vasicin in studies on rats and rabbits.

Representative

About 70 alkaloids with a quinazoline partial structure are known, which are usually further subdivided into simple quinazolinones , pyrroloquinazolines , pyrido [2,1- b ] - and indoloquinazolines based on their structure .

• 

  Vasicin

• 

  Evodiamine

• 

  Rutaecarpin

• 

  Febrifugin

Occurrence

The quinazoline alkaloids are mainly used in plants, such as in Acanthaceae ( Adhatoda vasica ), Rutaceae , Saxifragaceen ( Dichroa febrifuga ) and in Linaria TYPES ( Scrophulariaceae ) and Peganum harmala (Fam Zygophyllaceae.); also in animals (cf. tetrodotoxin ) and bacteria .

biosynthesis

It seems certain that one of the biosynthetic building blocks of the structurally related quinazoline alkaloids (as with the acridone alkaloids ) is anthranilic acid . The other starting materials are unknown.

Web links

Commons : Chinazoline Alkaloids  - Collection of Images, Videos, and Audio Files

Individual evidence

1. ↑ ^{a b c} Entry on peganine. In: Römpp Online . Georg Thieme Verlag, accessed on March 24, 2016.
2. ↑ Abortive effects of lungwort: Adhatoda Vasika: Vasaka ( Memento from June 11, 2014 in the Internet Archive ) (PDF; 62 kB).