Quinazoline

Structural formula
General
Surname	Quinazoline
other names	1,3-benzodiazine 1,3-diazanaphthalene Benzo [ d ] pyrimidine 4,5-benzopyrimidine Phenmiazine
Molecular formula	C 8 H 6 N 2
Brief description	light yellow solid
External identifiers / databases
CAS number 253-82-7 EC number 205-965-3 ECHA InfoCard 100.005.424 PubChem 9210 Wikidata Q426278
properties
Molar mass	130.15 g · mol -1
Physical state	firmly
Melting point	45-48 ° C
boiling point	243 ° C
safety instructions
GHS labeling of hazardous substances no GHS pictograms H and P phrases H: no H-phrases P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Quinazoline is an organic compound that belongs to the heterocycles (more precisely: heteroaromatics and diazanaphthalenes ). The connection consists of a benzene ring, to which a pyrimidine ring fused is. Quinazoline is isomeric to quinoxaline , cinnoline and phthalazine .

Derived Molecules

The naturally occurring quinazoline alkaloids , such as vasicine (peganine) and febrifugine , are derived from quinazoline .

Synthetic active ingredients such as the alpha blocker prazosin , the sleeping pill methaqualone and EGFR - tyrosine kinase inhibitors such as Gefitinib , Erlotinib , Lapatinib , AEE788 , EKB-569 and HKI-272 have a basic quinazoline structure.

Individual evidence

1. ↑ ^{a b c d} Data sheet Quinazoline, 98% at AlfaAesar, accessed on December 7, 2019 ( PDF )(JavaScript required) .
2. ↑ Data sheet for quinazoline from Acros, accessed December 19, 2019.
3. ↑ MJ Eck and C.-H. Yun: Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer. In: Biochimica et Biophysica Acta . 1804 (2010) pp. 559-566.